Infectious Disease Book

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RibavirinAka: Virazole, Rebetol

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  1. Indications
    1. Hepatitis C
    2. Respiratory Syncytial Virus (RSV)
      1. Aerosolized Ribavirin used in high risk infants
    3. Acute Hemorrhagic Fever (Intravenous or Oral Ribavirin)
      1. Arenavirus (Lassa Fever, AHF, BHF, VHF)
      2. Bunyaviridae (e.g. Hantavirus, Rift Valley Fever)
    4. Severe Influenza infection
      1. Intravenous or aerosolized
  2. Mechanism
    1. Antiviral guanosine analogue
  3. Adverse Effects
    1. Hemolytic Anemia
    2. Teratogenic (Pregnancy Class X)
      1. Men and women need to avoid conception for 6 months
  4. Dosing: Chronic Hepatitis C
    1. Dose <75 kg: 400 mg PO qAM and 600 mg PO qPM
    2. Dose >75 kg: 600 mg PO bid
    3. Dose if Hemolytic Anemia: 300 mg bid
    4. Cost: $2500 per 24 week course
  5. References
    1. (1999) Med Lett Drugs Ther 41(1054):53

Ribavirin (C0035525)

Definition (MSH)A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Definition (CSP)1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS.
Definition (NCI)A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
Definition (PDQ)A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C807" NCI Thesaurus)
Definition (NCI)A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. (NCI04)
ConceptsNucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
EnglishRIBA, Ribavirin, RIBAVIRIN PREPARATION, Ribovirin, RTCA, Tribavirin
Spanishribavirina, tribavirina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Rebetol (C1170576)

ConceptsNucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
EnglishEssex Brand of Ribavirin, Pharmacia Brand of Ribavirin, Rebetol, Schering Plough Brand of Ribavirin
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Virazole (C1622085)

ConceptsNucleic Acid, Nucleoside, or Nucleotide (T114) , Pharmacologic Substance (T121)
EnglishICN Brand of Ribavirin, Vilona, Virazole
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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