II. Indications

  1. Hepatitis C
  2. Respiratory Syncytial Virus (RSV)
    1. Aerosolized Ribavirin used in high risk infants
  3. Acute Hemorrhagic Fever (Intravenous or Oral Ribavirin)
    1. Arenavirus (Lassa Fever, AHF, BHF, VHF)
    2. Bunyaviridae (e.g. Hantavirus, Rift Valley Fever)
  4. Severe Influenza infection
    1. Intravenous or aerosolized

III. Mechanism

  1. Antiviral guanosine analogue

IV. Adverse Effects

  1. Hemolytic Anemia
  2. Teratogenic (Pregnancy Class X)
    1. Men and women need to avoid conception for 6 months

V. Dosing: Chronic Hepatitis C

  1. Dose <75 kg: 400 mg PO qAM and 600 mg PO qPM
  2. Dose >75 kg: 600 mg PO bid
  3. Dose if Hemolytic Anemia: 300 mg bid
  4. Cost: $2500 per 24 week course

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Cost: Medications

ribavirin (on 6/15/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
RIBAVIRIN 200 MG CAPSULE Generic $1.28 each

Ontology: Ribavirin (C0035525)

Definition (NCI) A synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses. Ribavirin is incorporated into viral RNA, thereby inhibiting viral RNA synthesis, inducing viral genome mutations, and inhibiting normal viral replication.
Definition (NCI_NCI-GLOSS) A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
Definition (MSH) A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Definition (CSP) 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS.
Definition (PDQ) A synthetic nucleoside analogue of ribofuranosyl with antiviral activity. Ribavirin incorporates into viral nucleic acid, inhibits viral ribonucleic acid (RNA) synthesis, induces viral genome mutations, and inhibits normal viral replication. Ribavirin shows activity against a variety of RNA viruses, especially hepatitis C virus. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40325&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C807" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH D012254
SnomedCT 346695009, 35063004, 387188005
LNC LP35809-0, MTHU018696
English Ribovirin, Tribavirin, 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-, 1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide, 1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide, ribavirin, Ribavirin, RIBAVIRIN, RIBA, ribavirin (medication), Ribavirin [Chemical/Ingredient], ribovirin, Tribavirin (product), 1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide, RTCA, Ribavirin (product), Ribavirin (substance)
Swedish Ribavirin
Czech ribavirin
Finnish Ribaviriini
Russian RIBOVARIN, RIBOVIRIN, RIBAVIRIN, TRIBAVIRIN, VIRAZOL, ВИРАЗОЛ, РИБАВИРИН, РИБОВАРИН, ТРИБАВИРИН, РИБОВИРИН
Japanese リボビリン, リバビリン, トリバビリン
Italian Tribavirina, Ribovirina, Ribavirina
Polish Rybawiryna
Croatian RIBAVIRIN
Spanish ribavirina (producto), ribavirina (sustancia), ribavirina, tribavirina, Ribavirina, Ribovirina, Tribavirina
French Ribavirine
German Ribavirin, Ribovirin, Tribavirin
Portuguese Ribavirina, Ribovirina, Tribavirina

Ontology: Rebetol (C1170576)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH D012254
English Ribavirin Merck Brand, Merck Brand of Ribavirin, Pfizer Brand of Ribavirin, rebetol, Rebetol, Essex Brand of Ribavirin

Ontology: Virazole (C1622085)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH D012254
English virazole, Virazole, ICN Brand of Ribavirin, Vilona