III. Pharmacology

  1. Imidazolyl derivative of mercaptopurine
    1. Metabolized to mercaptopurine as active ingredient
  2. Structural Analogue Chemotherapy (purine)

IV. Adverse Effects (similar to mercaptopurine)

  1. Bone Marrow suppression
    1. Leukopenia
    2. Anemia
    3. Thrombocytopenia
  2. Skin rash
  3. Drug Fever
  4. Nausea, Vomiting or Diarrhea
  5. Hepatic dysfunction (cholestasis, hepatitis)

V. Drug Interactions

  1. See Cytochrome P-450 3A4
  2. See Purine Synthesis Inhibitor
  3. Allopurinol may increase Azathioprine to toxic levels

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Cost: Medications

azathioprine (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
AZATHIOPRINE 50 MG TABLET Generic $0.42 each

Ontology: Azathioprine (C0004482)

Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (CHV) an immunosuppressive drug
Definition (NCI) A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
Definition (MSH) An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Definition (CSP) immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis; possible carcinogen.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D001379
SnomedCT 391800005, 327060009, 317390007, 111165009, 372574004
LNC LP18898-4, MTHU006794
English Azathioprine, Azothioprine, 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, Azathioprine [gastrointestinal], Azathioprine [gi], Azathioprine [immunosuppress], 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, azathioprine, Azathioprine [immunosuppressant], AZTP, azathioprine (medication), AZATHIOPRINE, Azathioprine [Chemical/Ingredient], atps, ATP, azothioprine, azaTHIOprine, AzaTHIOprine, Azathioprine - chemical (substance), Azathioprine [immunosuppressant] (product), Azathioprine - chemical, Azathioprine [gastrointestinal] (product), AZT - Azathioprine, Azathioprine (product), Azathioprine (substance), Azathioprine [gastrointestinal] (substance), AZA
Swedish Azatioprin
Czech azathioprin
Finnish Atsatiopriini
Italian Azotioprina, Azatioprina
Russian IMURAN, AZATIOPRIN, АЗАТИОПРИН, ИМУРАН
Japanese イムラン, アザチオプリン
Polish Azatiopryna
Spanish azatioprina (gastrointestinal) (producto), azatioprina (gastrointestinal), azatioprina (producto), azatioprina (sustancia), azatioprina, Azatioprina
French Azathioprine
German Azathioprin
Portuguese Azatioprina

Ontology: Imuran (C0699279)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D001379
English Immuran, imuran, immuran, Imuran
French Imuran
German Imuran, Immuran