Hematology and Oncology Book

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Microangiopathic Anemia

Aka: Microangiopathic Anemia, Microangiopathic Hemolytic Anemia, Fragmentation Hemolysis, MAHA
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  1. See Also
    1. Hemolytic Anemia
  2. Mechanism
    1. RBCs damaged by injured vessel endothelium
    2. Results in Schistocyte formation
  3. Causes
    1. Prosthetic Heart Valve
    2. Vasculitis
    3. Malignant Hypertension
    4. Eclampsia
    5. Renal graft rejection
    6. Giant Hemangioma
    7. Scleroderma
    8. Thrombotic Thrombocytopenic Purpura (TTP)
    9. Hemolytic Uremic Syndrome (HUS)
    10. Disseminated Intravascular Coagulation (DIC)
    11. March Hemoglobinuria (Marathon runners)
  4. Examination
    1. Blood Pressure
  5. Labs
    1. Peripheral Smear
      1. Schistocytes
    2. Liver Function Tests
    3. Renal Function Tests
    4. ProTime (PT)
    5. Partial Thromboplastin Time (aPTT)
  6. References
    1. Udden in Goldman (2000) Cecil Medicine. p. 882-4

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