II. Indications
-
Active Tuberculosis Treatment
- Used together with multiple other agents, typically 4 drug regimens
III. Contraindications
- Pregnancy
IV. Mechanism
- See Aminoglycoside
- Streptomycin is an Aminoglycoside antibiotic derived from Streptomyces griseus
V. Dosing: Tuberculosis Combination Therapy
- See Active Tuberculosis Treatment
- Adults
- Give 15 mg/kg (maximum 1 gram) IV or IM daily
- Older adults (age >60 years)
- Give 10 mg/kg (maximum 750 mg) IV or IM daily
- Children
- Give 20 to 40 mg/kg (maximum 1 gram) IM daily (FDA approved) OR
- Give 15 mg/kg (maximum 1 gram) IM daily (off label)
VI. Adverse Effects
- See Aminoglycoside
-
Aminoglycosides are associated with risk of Ototoxicity and nephrotoxicity (FDA black box warning)
- See Aminoglycoside for risk factors
VII. Safety
- Pregnancy Category D
- Considered safe in Lactation
- Monitoring (baseline and monthly)
- Audiogram
- Renal Function
- Vestibular Testing
- Rhomberg testing
VIII. Resources
- Streptomycin Injection Solution (DailyMed)