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Medication Causes of EdemaAka: Edema Secondary to Medications

Salt and water retention
1. Hydralazine
2. Diazoxide (Hyperstat)
3. Minoxidil
4. NSAIDs
5. Corticosteroids
6. Estrogen
7. Insulin
8. Thiazolidinedione (e.g. Actos, Avandia)
9. Phenothiazines
  1. Thioridazine (Mellaril)
  2. Chlorpromazine (Thorazine)
  3. Trifluoperazine (Stelazine)
  4. Thiothixene (Navane)
10. Diuretic Abuse or Laxative abuse
  1. Increases renin and aldosterone levels
  2. Rebound salt retention on stopping medication
Increased Vascular permeability
1. Interleukin-2
Miscellaneous Mechanisms
1. Docetaxel (Taxotere)
2. Pramipexole (Mirapex)

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 2/26/2010. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.