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Pregabalin

Aka: Pregabalin, Lyrica
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  1. Indications
    1. Anticonvulsant
      1. Adjunct for partial-onset Seizures
    2. Neuropathic Pain Management
      1. Fibromyalgia
      2. Peripheral Neuropathy
        1. Diabetic Peripheral Neuropathy
        2. Postherpetic Neuralgia
  2. Mechanism
    1. Alpha2-delta1 Ligand agent
    2. Binds alpha2-delta1 subunit of Central Nervous System voltage-gated calcium channels
    3. Does not bind GABA receptors or Benzodiazepine receptors
  3. Adverse effects
    1. Common adverse effects
      1. Weight gain
      2. Peripheral edema
      3. Dizziness or ataxia
      4. Somnolence
      5. Headache
      6. Xerostomia
      7. Tremor
      8. Blurred vision or Diplopia
    2. Severe but uncommon adverse effects
      1. Angioedema
      2. Hypersensitivity Reaction
      3. Rhabdomyolysis (rare)
  4. Dosing
    1. Starting: 25 mg orally three times daily (starting low dose maximizes tolerability)
    2. Titrate to effective dose in increments on weekly basis based on tolerability
    3. Maximum dose: 450 mg/day divided 2-3 times daily
      1. Fibromyalgia may require the maximum dose
    4. Stopping: Taper off agent (Do not stop abruptly due to withdrawal symptoms)
Medication Costs
Lyrica (on 2/9/2012 at DrugStore.com)
Lyrica 25mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 50mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 75mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 100mg Capsules #30 for $90.99 ($3.03/unit)
Lyrica 150mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 200mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 300mg Capsules #30 for $91.99 ($3.07/unit)
Lyrica 225mg Capsules #30 for $91.99 ($3.07/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

pregabalin (C0657912)

Definition (NCI) A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
Definition (NCI) A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Lyrica is a type of anticonvulsant.
Concepts Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSH C080245
SnomedCT 415159003, 415160008
English 3-(Aminomethyl)-5-methyl-hexanoic Acid, 3-Isobutyl GABA, pregabalin (medication), PREGABALIN, pregabalin [Chemical/Ingredient], Pregabalin (product), Pregabalin (substance), Pregabalin, 3-isobutyl GABA, pregabalin
Spanish pregabalina (producto), pregabalina (sustancia), pregabalina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Lyrica (C1570232)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C080245
English Lyrica
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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