II. Laxative Types

  1. Bulk Laxative
    1. Preferred agents (effective with few adverse effects)
    2. Psyllium (e.g. Metamucil)
    3. Methylcellulose (e.g. Ctrucel)
    4. Calcium Polycarbophil (Fibercon)
    5. Dietary Fiber
  2. Emollient Laxative (Stool Softener)
    1. DocusateSodium (Colace) - questionable efficacy
    2. Glycerin
    3. Mineral Oil (not recommended)
      1. Aspiration risk
      2. Depletes fat soluble Vitamins
  3. Osmotic Laxative
    1. Poorly absorbed saccharides (Lactulose, Sorbitol)
    2. Magensium Laxatives (Milk of Magnesia)
    3. Sodium bisphosphate (Fleets Phospho-Soda)
    4. Polyethylene glycol lavage solution (GoLytely)
  4. Stimulant Laxative (Risk of Laxative abuse)
    1. Other Laxative types are preferred over these
    2. Anthraquinone Laxative
      1. Cascara sagrada Extract (Casanthranol)
      2. Senna Extract (Senokot)
    3. Diphenylmethane Laxative
      1. Bisacodyl (Dulcolax)
      2. Phenolphthalein (OTC, Correctol, Ex-Lax)
  5. Combination Agents
    1. Peri-Colace contains Cascara and Docusate
    2. Senekot-S contains senna and Docusate
  6. Enemas and suppositories
    1. Never use hot water, soap, or hydrogen peroxide enema
    2. Tap water enema or saline enema (safest)
    3. Sodium Bisphosphate enema (Fleet Enema)
    4. Mineral Oil enema
    5. Glycerine suppository
    6. Bisacodyl suppository (dulcolax suppository)
  7. Prokinetic agents
    1. Tegaserod (Zelnorm)
      1. Indicated only in IBS for Constipation in women

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Cost: Medications

laxative (on 12/21/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
LAXATIVE 25 MG PILL Generic OTC $0.10 each
LAXATIVE 5 MG TABLET Generic OTC $0.05 each
LAXATIVE EC 5 MG TABLET Generic OTC $0.02 each
LAXATIVE FEMININE 5 MG TAB Generic OTC $0.05 each
LAXATIVE MAX STRENGTH PILLS Generic OTC $0.10 each

Ontology: Laxatives (C0282090)

Definition (CHV) a drug used to treat constipation by increasing bowel movement
Definition (CHV) a drug used to treat constipation by increasing bowel movement
Definition (NCI) Synthetic compounds or mixtures administered orally or rectally with laxative activity. A laxative preparation is used to promote bowel movement to treat constipation or to clean the colon for rectal and bowel examinations. There are different types of laxatives that differ in mechanism of action and potency, including the bulk-producing agents, stool softeners, lubricants, hydrating agents, stimulants, saline laxatives and hyperosmotic agents.
Definition (NCI_NCI-GLOSS) A substance that promotes bowel movements.
Definition (CSP) agent that acts to promote evacuation of the bowel; a cathartic or purgative.
Definition (MSH) Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
Concepts Pharmacologic Substance (T121)
MSH D054368
SnomedCT 317640001, 372800002, 61621000
LNC LP18988-3, MTHU007218
English Other laxatives, LAXATIVES,OTHER, LAXATIVES, Laxatives, laxatives (medication), laxatives, GI preparations laxatives, Laxative Preparation, [GA209] LAXATIVES,OTHER, [GA200] LAXATIVES, laxative, Other laxatives (product), Laxative, Laxative (product), Laxative (substance), Laxative, NOS, Other laxatives (substance), Mild cathartic
Portuguese Laxantes, Laxativos
Spanish Laxativos, otros laxantes, otros laxantes (producto), Laxantes, laxante (producto), laxante (sustancia), laxante
Finnish Ulostuslääkkeet
French Agents laxatifs, Médicaments laxatifs, Laxatifs
German Laxantien
Italian Lassativi
Russian LAKSATIVY, ЛАКСАТИВЫ
Czech projímadla, laxancia, laxativa
Swedish Avföringsmedel
Polish Leki przeczyszczające
Japanese 緩下剤, 緩下薬