Rheumatology Book

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Fatigue Causes

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  1. Causes: Psychogenic and lifestyle (80%)
    1. Mood Disorder
      1. Anxiety Disorder
      2. Major Depression
      3. Bipolar Disorder
    2. Eating disorder
      1. Anorexia Nervosa
      2. Bulimia Nervosa
    3. Sleep disorder (e.g. Insomnia)
    4. Recovery from surgery (Fatigue may persist 12 weeks even following minor surgery)
    5. Lifestyle
      1. Work problems or dissatisfaction
      2. Home finances and relationships
      3. Sedentary lifestyle and deconditioning
      4. Inadequate nutrition
      5. Inadequate rest or Overtraining
    6. Drug use
      1. Alcohol or Alcohol Abuse
      2. Tobacco
      3. Caffeine
      4. Amphetamines
      5. Sedative-Hypnotics medications or Tranquilizers
      6. Illicit Drug abuse
  2. Causes: Organic (20%)
    1. Infectious
      1. Febrile states
      2. Tuberculosis
      3. HIV Infection or AIDS
      4. Lyme Disease
      5. Chronic Mononucleosis
      6. Influenza
    2. Metabolic disorder
      1. Diabetes Mellitus
      2. Hypothyroidism or Hyperthyroidism
      3. Hyperparathyroidism
      4. Hypopituitarism
      5. Addison's Disease
      6. Cushing's Disease
    3. Hematologic Disorder
      1. Anemia
      2. Lymphoma
      3. Leukemia
      4. Occult malignancy
      5. Heavy metal toxicity (e.g. Lead Poisoning)
    4. Renal Disease
      1. Acute Renal Failure
      2. Chronic Renal Failure
    5. Liver Disease
      1. Acute Hepatitis
      2. Chronic hepatitis
      3. Cirrhosis
    6. Rheumatologic disease
      1. Fibromyalgia
      2. Sjogren's Syndrome
      3. Polymyalgia Rheumatica
      4. Giant Cell Arteritis
      5. Polymyositis or Dermatomyositis
      6. Connective tissue disease
      7. Inflammatory Bowel Disease
      8. Sarcoidosis
      9. Chronic Fatigue Syndrome
    7. Neurologic
      1. Multiple Sclerosis
      2. Parkinson's Disease
    8. Miscellaneous
      1. Sleep Apnea
      2. Coronary Artery Disease
      3. Chronic Obstructive Pulmonary Disease
    9. Medications
      1. Psychotropic medications
        1. Antidepressants
        2. Amitriptyline
        3. Doxepin
        4. Trazodone
      2. Antihistamines
        1. Diphenhydramine
        2. Non-Sedating Antihistamines cause Fatigue in up to 15% of patients
      3. Cardiovascular medications
      4. Opioids
      5. Antihypertensive medications
        1. Beta Blockers (e.g. Propranolol)
        2. Reserpine
        3. Methyldopa
        4. Clonidine
  3. References
    1. Lipken in Dornbrand (1992) Ambulatory Care, p. 5-8
    2. Goroll (2000) Primary Care Medicine, Lippincott, p. 41
    3. Rosenthal (2008) Am Fam Physician 78(10):1173

Fatigue (C0015672)

Definition (MSH)The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Definition (CSP)state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Definition (NCI)That state, following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability.
ConceptsSign or Symptom (T184)
ICD9780.79
MSHD005221
Englishdecreased energy, Fatigue, Lack of energy, Lacking in energy, Loss of energy, psychogenic fatigue, Tiredness, Weariness
Spanishcansancio, falta de energia, faltante de energia, fatiga, perdida de energia
Parent ConceptsMedical History (C0262926), Fatigue (C0015672), Dormancy (C0678686), body physical activity (C0178520), Signs and Symptoms (C0037088), Mental and Behavioral Signs and Symptoms (C0237088), cancer-related problem/condition (C0280950), [D]Malaise and fatigue NOS (C0024528), Finding of general energy (C0578015), Duplicate concept (C1274013), Energy and stamina finding (C1282984), General problem AND/OR complaint (C1290919)
SourcesAIR, AOD, COSTAR, CSP, CST, DXP, LCH, LNC, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, PDQ, PNDS, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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