Rheumatology Book

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Fatigue Causes

Aka: Fatigue Causes
  1. Causes: Psychogenic and lifestyle (80%)
    1. Mood Disorder
      1. Anxiety Disorder
      2. Major Depression
      3. Bipolar Disorder
    2. Eating disorder
      1. Anorexia Nervosa
      2. Bulimia Nervosa
    3. Sleep disorder (e.g. Insomnia)
    4. Recovery from surgery (Fatigue may persist 12 weeks even following minor surgery)
    5. Lifestyle
      1. Work problems or dissatisfaction
      2. Home finances and relationships
      3. Sedentary lifestyle and deconditioning
      4. Inadequate nutrition
      5. Inadequate rest or Overtraining
    6. Drug use
      1. Alcohol or Alcohol Abuse
      2. Tobacco
      3. Caffeine
      4. Amphetamines
      5. Sedative-Hypnotics medications or Tranquilizers
      6. Illicit Drug abuse
  2. Causes: Organic (20%)
    1. Infectious
      1. Febrile states
      2. Tuberculosis
      3. HIV Infection or AIDS
      4. Lyme Disease
      5. Chronic Mononucleosis
      6. Influenza
    2. Metabolic disorder
      1. Diabetes Mellitus
      2. Hypothyroidism or Hyperthyroidism
      3. Hyperparathyroidism
      4. Hypopituitarism
      5. Addison's Disease
      6. Cushing's Disease
    3. Hematologic Disorder
      1. Anemia
      2. Lymphoma
      3. Leukemia
      4. Occult malignancy
      5. Heavy metal toxicity (e.g. Lead Poisoning)
    4. Renal Disease
      1. Acute Renal Failure
      2. Chronic Renal Failure
    5. Liver Disease
      1. Acute Hepatitis
      2. Chronic hepatitis
      3. Cirrhosis
    6. Rheumatologic disease
      1. Fibromyalgia
      2. Sjogren's Syndrome
      3. Polymyalgia Rheumatica
      4. Giant Cell Arteritis
      5. Polymyositis or Dermatomyositis
      6. Connective tissue disease
      7. Inflammatory Bowel Disease
      8. Sarcoidosis
      9. Chronic Fatigue Syndrome
    7. Neurologic
      1. Multiple Sclerosis
      2. Parkinson's Disease
    8. Miscellaneous
      1. Sleep Apnea
      2. Coronary Artery Disease
      3. Chronic Obstructive Pulmonary Disease
    9. Medications
      1. Psychotropic medications
        1. Antidepressants
        2. Amitriptyline
        3. Doxepin
        4. Trazodone
      2. Antihistamines
        1. Diphenhydramine
        2. Non-Sedating Antihistamines cause Fatigue in up to 15% of patients
      3. Cardiovascular medications
      4. Opioids
      5. Antihypertensive medications
        1. Beta Blockers (e.g. Propranolol)
        2. Reserpine
        3. Methyldopa
        4. Clonidine
  3. References
    1. Lipken in Dornbrand (1992) Ambulatory Care, p. 5-8
    2. Goroll (2000) Primary Care Medicine, Lippincott, p. 41
    3. Rosenthal (2008) Am Fam Physician 78(10): 1173-9

Fatigue (C0015672)

Definition (NCI) A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.
Definition (MEDLINEPLUS)

You‘re tired, weak, exhausted, weary, worn out. You have a lack of energy and as a result you feel distressed. You’re not functioning as well as you should. It’s called fatigue, and everyone feels it at times.

Acute fatigue is normal tiredness with occasional symptoms that begin quickly and last for a short time. Rest may help ease acute fatigue and let you return to your normal activities. Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities. Fatigue may also accompany other conditions, including pregnancy, anemia, or cancer, or may result from medicines or emotional problems.

Fatigue is a common symptom. Your health care provider can help find the cause and recommend ways to relieve it.
Definition (NCI) A survey question about whether a person has experienced a lack of energy.
Definition (NCI) A condition marked by extreme tiredness and inability to function due lack of energy. Fatigue may be acute or chronic.
Definition (NCI) That state, following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency or accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability. (On-line Medical Dictionary)
Definition (NCI) I have a lack of energy.
Definition (HHC) Exhaustion that interferes with physical and mental activities.
Definition (NAN) An overwhelming sustained sense of exhaustion and decreased capacity for physical and mental work at usual level
Definition (MSH) The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Definition (CSP) state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Concepts Sign or Symptom (T184)
MSH D005221
ICD10 R53.83
SnomedCT 206767001, 206771003, 302758002, 158169005, 139126000, 84229001, 248274002, 367392001
French FATIGUE, Fatigue extrême, Perte d'énergie, Energie diminuée, Ereinté, Lassitude, Sensation de manque total d'énergie, EPUISEMENT, FAIBLESSE, LASSITUDE, Fatigue
English FATIGUE, FATIGUE EXTREME, Fatigued, TIREDNESS, WEARINESS, [D]Fatigue, [D]Tiredness, [D]Fatigue (context-dependent category), [D]Tiredness (context-dependent category), Extreme fatigue, Decreased energy, decreased energy, tiredness, fatigue (diagnosis), fatigue, Tiredness (finding), [D]Fatigue (situation), Feeling of total lack of energy, Fatigue extreme, Tired out, [D]Tiredness (situation), Fatigue NOS, Fatigue [Disease/Finding], rndx fatigue (diagnosis), rndx fatigue, fatigu, lacking energy, fatigues, fatigus, loss of energy, tired time, fatigue extreme, extreme fatigue, weariness, fatigued, tatt, time tired, energy loss, fatiguing, tired all the time, Lack Energy, Energy decreased, Tiredness, Lack of energy, Loss of energy, Weariness, Fatigue (finding), Lack of energy (finding), Lacking in energy, Lacking in energy (finding), Fatigue, Lack of Energy, lack of energy, Lack (of);energy
Portuguese FADIGA, Fadiga extrema, Sensação de falta total de energia, Perda de energia, Exausto, Energia diminuída, CANSACO, ESGOTAMENTO, EXAUSTAO, Fadiga
Spanish FATIGA, Abatimiento, Sensación de falta absoluta de energía, Pérdida de energía, Fatiga extrema, Cansado, Cansancio, Falta de energía, [D]cansancio (categoría dependiente del contexto), faltante de energía (hallazgo), [D]fatiga (categoría dependiente del contexto), faltante de energía, Fatigue, Tiredness, [D]Fatigue, ABATIMIENTO, CANSANCIO, FATIGA EXTREMA, [D]cansancio, [D]cansancio (situación), [D]fatiga (situación), [D]fatiga, cansancio, falta de energía (hallazgo), falta de energía, fatiga (hallazgo), fatiga, pérdida de energía, Fatiga
German ERMUEDUNG, Mangel an Energie, Muedigkeit extrem, Ueberdruss, Energie abgenommen, abgeschlafft, Gefuehl voelligen Energiemangels, Muedigkeit, ABGESCHLAGENHEIT, MUEDIGKEIT STARK, MUEDIGKEIT, Ermuedung, Ermüdung, Müdigkeit
Italian Affaticamento, Affaticamento estremo, Esaurito, Sensazione di totale mancanza di energia, Perdita di energia, Energia ridotta, Stanchezza
Dutch vermoeid, moeheid, uitzonderlijk moe, verlies van energie, gevoel van energieloosheid, energie afgenomen, vermoeidheid, Moeheid
Japanese 活力低下, 活力喪失感, 活力喪失, 疲労困ぱい, 極度の疲労, 疲労, ﾋﾛｳｺﾝﾊﾟｲ, ｶﾂﾘｮｸﾃｲｶ, ｶﾂﾘｮｸｿｳｼﾂｶﾝ, ﾋﾛｳ, ｷｮｸﾄﾞﾉﾋﾛｳ, ｶﾂﾘｮｸｿｳｼﾂ
Swedish Trötthet
Czech únava, Utahanost, Extrémní únava, Utahaný, Ztráta energie, Úbytek energie, Únava, Vyčerpanost, Pocit celkového nedostatku energie
Finnish Väsymys
Russian UTOMLENIE, USTALOST', УСТАЛОСТЬ, УТОМЛЕНИЕ
Croatian UMOR
Polish Znużenie, Zmęczenie
Hungarian Kimerültség, Defatigatio, Kifáradt, Teljes energiahiány érzete, Energia elvesztése, Fáradtság, Kimerültség, extrém, Csökkent energia
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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