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Fatigue Causes

Causes: Psychogenic and lifestyle (80%)
1. Mood Disorder
2. Eating disorder
  1. Anorexia Nervosa
  2. Bulimia Nervosa
3. Sleep disorder (e.g. Insomnia)
4. Lifestyle
  1. Work problems or dissatisfaction
  2. Home finances and relationships
  3. Sedentary lifestyle
  4. Inadequate nutrition
  5. Inadequate rest
5. Drug use
  1. Alcohol or Alcohol Abuse
  2. Tobacco
  3. Caffeine
  4. Amphetamines
  5. Sedative-Hypnotics medications or Tranquilizers
  6. Illicit Drug abuse
Causes: Organic (20%)
1. Infectious
  1. Febrile states
  2. Tuberculosis
  3. HIV Infection or AIDS
  4. Lyme Disease
  5. Chronic Mononucleosis
  6. Influenza
2. Metabolic disorder
  1. Diabetes Mellitus
  2. Hypothyroidism or Hyperthyroidism
  3. Hyperparathyroidism
  4. Hypopituitarism
  5. Addison's Disease
  6. Cushing's Disease
3. Hematologic Disorder
  1. Anemia
  2. Lymphoma
  3. Leukemia
  4. Occult malignancy
  5. Heavy metal toxicity (e.g. Lead Poisoning)
4. Renal Disease
  1. Acute Renal Failure
  2. Chronic Renal Failure
5. Liver Disease
  1. Acute Hepatitis
  2. Chronic hepatitis
  3. Cirrhosis
6. Rheumatologic disease
  1. Fibromyalgia
  2. Sjogren's Syndrome
  3. Polymyalgia Rheumatica
  4. Giant Cell Arteritis
  5. Polymyositis or Dermatomyositis
  6. Connective tissue disease
  7. Inflammatory Bowel Disease
  8. Sarcoidosis
  9. Chronic Fatigue Syndrome
7. Neurologic
  1. Multiple Sclerosis
  2. Parkinson's Disease
8. Miscellaneous
9. Medications
  1. Psychotropic medications
    1. Amitriptyline
    2. Doxepin
    3. Trazodone
  2. Antihistamines (e.g. Diphenhydramine)
  3. Cardiovascular medications
  4. Antihypertensive medications
    1. Beta Blockers (e.g. Propranolol)
    2. Reserpine
    3. Methyldopa
    4. Clonidine
References
1. Lipken in Dornbrand (1992) Ambulatory Care, p. 5-8
2. Goroll (2000) Primary Care Medicine, Lippincott, p. 41

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.