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Depression Provoking MedicationsAka: Medications Predisposing to Depression, Medication Causes of Depression, Suicidality Associated with Medications

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  1. Causes: Suicidality associated with medications
    1. Varenicline (Chantix)
    2. Anticonvulsants
    3. Antidepressants in teens
    4. Singulair is being investigated for possible increased Suicidality
      1. (2008) Prescriber's Letter 15(5): 27-8
    5. Accutane does not appear to increase risk despite early reports
      1. Marqueling (2007) Semin Cutan Med Surg 26(4):210
  2. Causes: Recreational or Illicit Drug use
    1. Alcohol Abuse
    2. Benzodiazepine
    3. Barbiturate
    4. Narcotic or opiate intoxication
    5. Amphetamine withdrawal
    6. Cocaine withdrawal
    7. Anabolic Steroid use
    8. Phencyclidine (PCP)
    9. Marijuana
  3. Causes: Antihypertensive medication
    1. Highest risk
      1. Beta Blockers (Propranolol)
      2. Reserpine (Depletes Catecholamines)
      3. Methyldopa (Depletes Catecholamines)
    2. Low risk
      1. Clonidine (Catapres)
      2. Thiazide Diuretics
      3. Guanethidine
      4. Prazosin
      5. Hydralazine
    3. No risk
      1. ACE Inhibitors
      2. Calcium Channel Blockers
      3. Diuretics
  4. Causes: Gastrointestinal agents
    1. Metoclopramide (Reglan)
    2. Ranitidine
    3. Cimetidine
  5. Causes: Chemotherapeutic medications
    1. 6-Azauridine
    2. Asparaginase
    3. Azathioprine (Imuran)
    4. Bleomycin
    5. Cisplatin
    6. Cyclophosphamide
    7. Doxorubicin
    8. Mithramycin
    9. Vinblastine
    10. Vincristine
  6. Causes: Neurologic Agents
    1. Anti-parkinsonian Medications
      1. Amantadine
      2. Bromocriptine
      3. Levodopa
    2. Anti-Seizure Medications
      1. Carbamazepine (Tegretol)
      2. Ethosuximide (Zarontin)
      3. Phenobarbital
      4. Phenytoin (Dilantin)
      5. Primidone
  7. Causes: Psychotropic agents
    1. Catecholamine receptor blockers
      1. Fluphenazine (Prolixin)
      2. Haloperidol (Haldol)
    2. Sedatives
      1. Barbiturates
      2. Benzodiazepines
  8. Causes: Other medications
    1. Baclofen
    2. Cycloserine
    3. Disulfiram (Antabuse)
    4. NSAIDs
    5. Sulfonamides
    6. Corticosteroids
    7. Digitalis Glycosides (Digoxin)
    8. Oral Contraceptives
    9. Isoniazid
  9. References
    1. Beers (1990) Drugs 40(6):792
    2. Citrome (1994) Postgrad Med 95(1):137
    3. Ferris (1995) Depression Primary Care, PGM, p.36-44
    4. Kuzel (1996) Postgrad Med 99(5):179

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