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LamotrigineAka: Lamictal

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  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
  2. Adverse Effects: Dose related
    1. Dizziness
    2. Incoordination
    3. Tremor
    4. Ataxia
    5. Diplopia
    6. Headache
    7. Insomnia
    8. Somnolence
    9. Blurred vision
    10. Nausea or Vomiting
  3. Adverse Effects: Other
    1. Steven's Johnson Syndrome
    2. Aplastic Anemia
    3. Thrombocytopenia
    4. Neutropenia
    5. Pancytopenia
  4. Drug Interactions
    1. Antiepileptic agents (especially Valproic Acid)
  5. Dosing: Adults
    1. Initial: 25 mg every other day for 2 weeks
    2. Next: 25 mg PO qd for 2 weeks
    3. Target dose: 50-100 mg PO bid
    4. Maximum dose: 400 mg/day

lamotrigine (C0064636)

Definition (PDQ)A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38703" NCI Thesaurus)
Definition (NCI)A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC047781
Englishlamotrigine, LAMOTRIGINE PREPARATION
Spanishlamotrigina
Parent ConceptsAnticonvulsants (C0003286), Triazines (C0040877), Phenyltriazine derivative anticonvulsant (C1445641), Glutamate Reducing Agents (C1579355)
SourcesCSP, LNC, MSH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Lamictal (C0678180)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC047781
EnglishDesitin Brand of Lamotrigine, Glaxo Wellcome Brand of Lamotrigine, GlaxoSmithKline Brand of Lamotrigine, Lamictal, Lamiktal
SourcesMSH, MTH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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