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LamotrigineAka: Lamictal

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  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
  2. Adverse Effects: Dose related
    1. Dizziness
    2. Incoordination
    3. Tremor
    4. Ataxia
    5. Diplopia
    6. Headache
    7. Insomnia
    8. Somnolence
    9. Blurred vision
    10. Nausea or Vomiting
  3. Adverse Effects: Other
    1. Steven's Johnson Syndrome
    2. Aplastic Anemia
    3. Thrombocytopenia
    4. Neutropenia
    5. Pancytopenia
  4. Drug Interactions
    1. Antiepileptic agents (especially Valproic Acid)
  5. Dosing: Adults
    1. Initial: 25 mg every other day for 2 weeks
    2. Next: 25 mg PO qd for 2 weeks
    3. Target dose: 50-100 mg PO bid
    4. Maximum dose: 400 mg/day

lamotrigine (C0064636)

Definition (PDQ)A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38703" NCI Thesaurus)
Definition (NCI)A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishlamotrigine, LAMOTRIGINE PREPARATION
Spanishlamotrigina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Lamictal (C0678180)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishDesitin Brand of Lamotrigine, Glaxo Wellcome Brand of Lamotrigine, GlaxoSmithKline Brand of Lamotrigine, Lamictal, Lamiktal
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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