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Lamotrigine

Aka: Lamotrigine, Lamictal
  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
  2. Adverse Effects: Dose related
    1. Dizziness
    2. Incoordination
    3. Tremor
    4. Ataxia
    5. Diplopia
    6. Headache
    7. Insomnia
    8. Somnolence
    9. Blurred vision
    10. Nausea or Vomiting
  3. Adverse Effects: Other
    1. Steven's Johnson Syndrome
    2. Aplastic Anemia
    3. Thrombocytopenia
    4. Neutropenia
    5. Pancytopenia
  4. Drug Interactions
    1. Antiepileptic agents (especially Valproic Acid)
  5. Dosing: Adults
    1. Initial: 25 mg every other day for 2 weeks
    2. Next: 25 mg PO qd for 2 weeks
    3. Target dose: 50-100 mg PO bid
    4. Maximum dose: 400 mg/day

Lamictal (C0678180)

Definition (CHV) brand name of lamotrigine
Definition (CHV) brand name of lamotrigine
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C047781
English lamotrigine (Lamictal), lamictal, lamictal [brand name], LaMICtal, Lamiktal, Desitin Brand of Lamotrigine, Glaxo Wellcome Brand of Lamotrigine, GlaxoSmithKline Brand of Lamotrigine, Lamictal
Sources
Derived from the NIH UMLS (Unified Medical Language System)


lamotrigine (C0064636)

Definition (NCI) A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants.
Definition (NCI) A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)
Definition (PDQ) A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=328241&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C38703" NCI Thesaurus)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C047781
SnomedCT 387562000, 96195007
English lamotrigine, 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine, lamotrigine (medication), LAMOTRIGINE, lamotrigine [Chemical/Ingredient], lamoTRIgine, Lamotrigine, Lamotrigine (product), Lamotrigine (substance)
Spanish lamotrigina (producto), lamotrigina (sustancia), lamotrigina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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