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Acute Sinusitis ManagementAka: Sinusitis Management, Acute Bacterial Rhinosinusitis
- See Also
- Management: General Measures
- Symptomatic relief
- Warm, moist compresses over sinuses
- Tylenol
- Nasal Saline spray (2% buffered saline)
- Effective Decongestant
- Also use as pretreatment prior to Intranasal Steroid
- Effective in recurrent Sinusitis when used daily
- Systemic Decongestants
- Mucolytic
- Guaifenesin (e.g. Mucinex) 600 to 1200 mg PO bid
- Combination Mucolytic with Decongestant
- Entex PSE bid
- Topical Decongestants (Maximum of 3 days of use)
- Intranasal Steroids (treat for 3-6 weeks minimum)
- Avoid Antihistamines
- Dry secretions
- Impede osteomeatal complex drainage
- Symptomatic relief
- Management: Antibiotics
- Indicated only in acute bacterial Sinusitis
- See Acute Sinusitis for Diagnosis
- See Sinusitis Prediction Rules
- Protocol
- Antibiotic course
- Minimum course: 10-14 days
- Longer course for persistent symptoms: 28 days
- Change antibiotic if no improvement in 3 days
- Beta-lactamase resistance in acute cases: <30%
- Beta-lactamase resistance in chronic cases: 40-50%
- Antibiotic course
- First-Line
- Indications to start on first-line agents
- Mild to moderate symptoms
- No daycare exposure
- No recent antibiotic use
- Amoxicillin
- Adult: 500-1000 mg PO tid (higher dose recommended)
- Child: 90 mg/kg/day divided bid to tid (high dose)
- Disadvantages: Misses Beta-lactamase producers
- Trimethoprim Sulfamethoxazole (Bactrim, Septra)
- No longer recommended as first-line agent
- Higher resistance rate than other agents
- Dosing
- Adult: 160 TMP and 800 SMZ bid
- Child: 8 mg/kg/day TMP,40 mg/kg/day SMZ div. bid
- Disadvantages
- Misses Staphylococcus
- Risk of Toxic Epidermal Necrolysis
- Risk of Steven's Johnson Syndrome
- No longer recommended as first-line agent
- Indications to start on first-line agents
- Second-Line
- Indications to start on second-line agents
- Severe symptoms
- Daycare exposure
- Recent antibiotic use
- Amoxicillin-Clavulanate (Augmentin)
- Adult: 875 mg PO bid or 500 mg PO tid
- Child
- TID: 40 mg/kg/day divided q8 hours
- BID: 45 mg/kg/day divided q12 hours
- Cefuroxime (Zinacef, Ceftin)
- Adult: 250 to 500 mg PO bid
- Child: 30 mg/kg/day divided bid
- Cefpodoxime (Vantin)
- Adult: 200 mg PO bid
- Child: 10 mg/kg/day once daily
- Cefdinir (Omnicef)
- Adult: 300 mg PO bid or 600 mg PO qd
- Child: 14 mg/kg/day divided qd-bid
- Avoid Cefixime
- Poor Gram Positive Bacteria coverage
- Indications to start on second-line agents
- Third Line
- Consider adding Flagyl to second-line agents
- Consider second-line agent for longer course (4 week)
- Fluoroquinolones (avoid under age 16 years)
- Levofloxacin (Levaquin) 500 mg daily
- Moxifloxacin (Avelox) 400 mg daily
- Gatifloxacin (Tequin) 400 mg daily
- Indicated only in acute bacterial Sinusitis
- Management: Penicillin or Cephalosporin Allergy
- Macrolide antibiotics (High bacterial resistance rate)
- Trimethoprim-Sulfamethoxazole (Bactrim, Septra)
- Increasing bacterial resistance
- Other agents are preferred for Sinusitis
- Clindamycin (Cleocin)
- Consider in combination with Rifampin if severe
- Poor efficacy against Gram Negative Bacteria
- Fluoroquinolones (avoid under age 16 years)
- See Third line agents above
- Referral Indications to ENT
- See Also Sinus Surgery
- Sinusitis refractory to maximal medical management
- Recurrent Acute Sinusitis
- Persistent Chronic Sinusitis Symptoms
- Complicated Sinusitis
- Immunocompromised patient
- Toxic appearance
- Suspected contiguous orbital or cerebral involvement
- See red flag symptoms in Acute Sinusitis
- Sphenoid and Frontal Sinusitis are higher risk
- References
