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Cough ExpectorantAka: Protussive, Guaifenesin, Robitussin, Humibid, Liquibid, Guaifenex

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  1. See Also
    1. Cough Suppressant
    2. Cough Symptomatic Treatment
  2. Indications
    1. Infectious cough (may speed recovery)
    2. Chronic Bronchitis (clear airway mucus)
    3. Acute Sinusitis (assists with sinus drainage)
  3. Guaifenesin
    1. Short acting agents (e.g. Robitussin)
      1. Ages 2 to 5 years old: 2.5 ml PO q4h
      2. Ages 6 to 12 years old: 5 ml PO q4h
      3. Adults: 10 ml PO q4h
    2. Long acting agents
      1. Mucinex (Over-the-counter)
      2. Humabid LA with new, unproven formulation
        1. Contains guiacolsulfonate (old expectorant)
    3. Discontinued agents
      1. Prior Humibid LA, Liquibid, Guaifenex LA
    4. Effect
      1. The only effective expectorant medication per FDA
      2. Paradoxically also reduces cough in URI
        1. Due to altered cough receptor sensitivity in URI
        2. Dicpinigaitis (2003) Chest 124:2178
  4. Other Expectorant Preparations (use with caution)
    1. Nebulized hypertonic saline
      1. Used to induce Sputum for Sputum exam and culture
    2. Terbutaline (Brethine)
      1. Beta adrenergic agonist (tachycardia risk)
      2. Dose (age >12): 2.5 to 5 mg PO q6 hours while awake
    3. Amiloride (Midamor)
      1. Potassium sparing Diuretic

Guaifenesin (C0018305)

Definition (MSH)An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
Definition (NCI)A glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD006140
Englishalpha-Glyceryl guaiacol ether, Glycerol Guaiacolate, Glyceryl Guaiacolate, Guaiacol Glyceryl Ether, Guaianesin, Guaifenesin, Guaifenesin - chemical, GUAIFENESIN PREPARATION, Guaiphenesin, Guaiphenezine
Spanisheter de alfagliceril guayacolato, gliceril guayacolato, guaifenesina, guaifenesina - sustancia quimica, guayanesina
Parent ConceptsGuaiacol (C0018304), Expectorants (C0015314), Mucolytic Agents (C0026698), [RE302] NON-OPIOID-CONTAINING ANTITUSSIVES/EXPECTORANTS (C0973624), Respiratory smooth muscle relaxant (C0304440), Duplicate concept (C1274013), Guaifenesin and derivatives (C1445638), Respiratory Tract Agents, Other (C1579394)
SourcesLNC, MSH, MTH, MTHFDA, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Guaifenex (C0720747)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishGuaifenex
SourcesRXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Liquibid (C0721382)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishLiquibid
SourcesRXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Robitussin (C0723110)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishRobitussin
SourcesRXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Humibid (C0729017)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD006140
EnglishHumibid
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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