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Selective Aldosterone Receptor AntagonistAka: Selective Aldosterone Blocker, Eplerenone, Inspra
- Mechanism
- Selective Aldosterone Receptor Antagonist
- More selective for aldosterone than Spironolactone
- Indication
- Congestive Heart Failure
- Hypertension
- Contraindications
- Serum Potassium >5.5 mEq/L
- Tyep II Diabetes Mellitus with Microalbuminuria
- Renal insufficiency
- Serum Creatinine >2.0 in men or >1.8 mg/dl in women
- Creatinine Clearance <50 ml/min
- Adverse Effects
- Hyperkalemia
- Hypertriglyceridemia
- Hyponatremia
- Dizziness
- Fatigue
- Diarrhea
- Cough
- Less Gynecomastia and Impotence than Spironolactone
- Drug Interactions
- Potassium supplements
- Potassium sparing Diuretics
- Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
- ACE Inhibitors
- References
- (2003) Lexi-Comp Drug Database
- (2003) Med Lett Drugs Ther 45(1156):39
- Stier (2003) Heart Dis 5(2):102
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| Definition (NCI) | A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerone is used in the treatment of hypertension and congestive heart failure. |
| Concepts | Steroid (T110)
, Pharmacologic Substance (T121)
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| English | eplerenone, EPLERENONE PREPARATION |
| Spanish | eplerenona |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Steroid (T110)
, Pharmacologic Substance (T121)
|
| English | Inspra, Pharmacia brand of eplerenone |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
|
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