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Coronary Artery Disease

Congestive Heart Failure

Electrocardiogram

Examination

Hypertension

Inotrope

Hyperlipidemia

Pericardial Disorders

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Selective Aldosterone Receptor Antagonist

Aka: Selective Aldosterone Receptor Antagonist, Selective Aldosterone Blocker, Eplerenone, Inspra
  1. Mechanism
    1. Selective Aldosterone Receptor Antagonist
    2. More selective for aldosterone than Spironolactone
  2. Indication
    1. Congestive Heart Failure
    2. Hypertension
  3. Contraindications
    1. Serum Potassium >5.5 mEq/L
    2. Tyep II Diabetes Mellitus with Microalbuminuria
    3. Renal insufficiency
      1. Serum Creatinine >2.0 in men or >1.8 mg/dl in women
      2. Creatinine Clearance <50 ml/min
  4. Adverse Effects
    1. Hyperkalemia
    2. Hypertriglyceridemia
    3. Hyponatremia
    4. Dizziness
    5. Fatigue
    6. Diarrhea
    7. Cough
    8. Less Gynecomastia and Impotence than Spironolactone
  5. Drug Interactions
    1. Potassium supplements
    2. Potassium sparing Diuretics
    3. Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
    4. ACE Inhibitors
  6. References
    1. (2003) Lexi-Comp Drug Database
    2. (2003) Med Lett Drugs Ther 45(1156):39-40
    3. Stier (2003) Heart Dis 5(2):102-18

Inspra (C1144054)

Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C414690
English Inspra, Pfizer brand of eplerenone, inspra
Sources
Derived from the NIH UMLS (Unified Medical Language System)


eplerenone (C0961485)

Definition (NCI) A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.
Concepts Steroid (T110) , Pharmacologic Substance (T121)
MSH C414690
SnomedCT 398699008, 407010008
English 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester, eplerenone (medication), eplerenon, EPLERENONE, eplerenone [Chemical/Ingredient], eplerenone, Eplerenone (product), Eplerenone (substance), Eplerenone
Spanish eplerenona (producto), eplerenona (sustancia), eplerenona
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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