http://www.fpnotebook.com/
Selective Aldosterone Receptor AntagonistAka: Selective Aldosterone Blocker, Eplerenone, Inspra
- Mechanism
- Selective Aldosterone Receptor Antagonist
- More selective for aldosterone than Spironolactone
- Indication
- Contraindications
- Serum Potassium >5.5 mEq/L
- Tyep II Diabetes Mellitus with Microalbuminuria
- Renal insufficiency
- Serum Creatinine >2.0 in men or >1.8 mg/dl in women
- Creatinine Clearance <50 ml/min
- Adverse Effects
- Drug Interactions
- Potassium supplements
- Potassium sparing Diuretics
- Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
- ACE Inhibitors
- References
- (2003) Lexi-Comp Drug Database
- (2003) Med Lett Drugs Ther 45(1156):39
- Stier (2003) Heart Dis 5(2):102
eplerenone (C0961485) | |
|---|---|
| Definition (NCI) | A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerone is used in the treatment of hypertension and congestive heart failure. |
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) |
| MSH | C414690 |
| English | eplerenone, EPLERENONE PREPARATION |
| Spanish | eplerenona |
| Parent Concepts | Antihypertensive Agents (C0003364), Steroids (C0038317), [CV704] POTASSIUM-SPARING/COMBINATIONS DIURETICS (C0973516), Unclassified Ingredients (C1372954), Aldosterone Antagonists (C0002007), Aldosterone Receptor Antagonists (C1579268) |
| Sources | MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Inspra (C1144054) | |
|---|---|
| Concepts | Steroid (T110) , Pharmacologic Substance (T121) |
| MSH | C414690 |
| English | Inspra, Pharmacia brand of eplerenone |
| Sources | MSH, NCI, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
