Cardiovascular Medicine Book

Congestive Heart Failure

Coronary Artery Disease

Electrocardiogram

Examination

Hyperlipidemia

Hypertension

Miscellaneous

Pericardial Disorders

Obstetrics Chapter related topics

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Selective Aldosterone Receptor AntagonistAka: Selective Aldosterone Blocker, Eplerenone, Inspra

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  1. Mechanism
    1. Selective Aldosterone Receptor Antagonist
    2. More selective for aldosterone than Spironolactone
  2. Indication
    1. Congestive Heart Failure
    2. Hypertension
  3. Contraindications
    1. Serum Potassium >5.5 mEq/L
    2. Tyep II Diabetes Mellitus with Microalbuminuria
    3. Renal insufficiency
      1. Serum Creatinine >2.0 in men or >1.8 mg/dl in women
      2. Creatinine Clearance <50 ml/min
  4. Adverse Effects
    1. Hyperkalemia
    2. Hypertriglyceridemia
    3. Hyponatremia
    4. Dizziness
    5. Fatigue
    6. Diarrhea
    7. Cough
    8. Less Gynecomastia and Impotence than Spironolactone
  5. Drug Interactions
    1. Potassium supplements
    2. Potassium sparing Diuretics
    3. Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
    4. ACE Inhibitors
  6. References
    1. (2003) Lexi-Comp Drug Database
    2. (2003) Med Lett Drugs Ther 45(1156):39
    3. Stier (2003) Heart Dis 5(2):102

eplerenone (C0961485)

Definition (NCI)A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerone is used in the treatment of hypertension and congestive heart failure.
ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHC414690
Englisheplerenone, EPLERENONE PREPARATION
Spanisheplerenona
Parent ConceptsAntihypertensive Agents (C0003364), Steroids (C0038317), [CV704] POTASSIUM-SPARING/COMBINATIONS DIURETICS (C0973516), Unclassified Ingredients (C1372954), Aldosterone Antagonists (C0002007), Aldosterone Receptor Antagonists (C1579268)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Inspra (C1144054)

ConceptsSteroid (T110) , Pharmacologic Substance (T121)
MSHC414690
EnglishInspra, Pharmacia brand of eplerenone
SourcesMSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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