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Potassium-Sparing DiureticAka: Aldosterone Antagonist, Amiloride, Midamor, Triamterene, Dyrenium
- Preparations
- Potassium-sparing Diuretics only
- Amiloride (Midamor)
- Triamterene (Dyrenium)
- Potassium-sparing Diuretic and Aldosterone Antagonists
- Spironolactone (Aldactone)
- Eplerenone (Inspra)
- Drug Interactions
- Potassium supplements (risk of Hyperkalemia)
- CYP3A4 Inhibitors (Eplerenone only)
- Significantly increases Eplerenone levels
Aldosterone Antagonists (C0002007)
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| Definition (MSH) | Compounds which inhibit or antagonize the biosynthesis or actions of aldosterone. |
| Definition (CSP) | agent that counteracts or opposes the action of aldosterone. |
| Concepts | Pharmacologic Substance (T121)
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| English | ALDOSTERONE ANTAG, Aldosterone antagonist, Aldosterone Antagonists, aldosterone inhibitor |
| Spanish | antagonista de aldosterona, antagonista de la aldosterona, antagonistas de aldosterona, antagonistas de la aldosterona |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Definition (MSH) | A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) |
| Definition (CSP) | pyrazine compound inhibiting sodium reabsorbtion through sodium channels in renal epithelial cells; used in conjunction with diuretics to spare potassium loss. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Amiloride, AMILORIDE PREPARATION, Amipramizide |
| Spanish | amilorida |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Cahill May Roberts Brand of Amiloride Hydrochloride, Merck Brand of Amiloride Hydrochloride, Merck Sharp & Dohme Brand of Amiloride Hydrochloride, Midamor, Modamide |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Definition (MSH) | A pteridine that is used as a mild diuretic. |
| Definition (NCI) | A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+. |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Triamterene, TRIAMTERENE PREPARATION |
| Spanish | triamtereno |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Dyrenium, Wellspring Brand of Triamterene |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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