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Digoxin ToxicityAka: Digitalis Toxicity, Digibind, Digoxin-Immune Fab
- Epidemiology
- Risk Factors
- Hypokalemia
- Hypomagnesemia
- Hypercalcemia
- Medication use interfering with Digoxin excretion
- Symptoms
- Anorexia
- Nausea
- Vomiting
- Somnolence
- Muscle Weakness
- Diarrhea
- Yellow vision (xanthopsia)
- Labs
- Serum Digoxin Level over 2.5 mg/ml
- Does not always correlate with toxicity
- Toxicity may occur at low levels and not at high ones
- Electrocardiogram
- Dysrhythmia
- Premature beats
- Bigeminy
- Paroxysmal Atrial Tachycardia with 2:1 AV Block
- Atrial Fibrillation
- Nodal rhythm
- Ventricular Tachycardia
- T Wave inversion
- ST Depression
- PR interval increased
- Dysrhythmia
- Serum Digoxin Level over 2.5 mg/ml
- Management
- Stop Digoxin
- Correct Hypokalemia
- Use caution if Heart Block is present
- Treat associated arrhythmias appropriately
- Avoid potentially harmful interventions
- Catecholamines
- Electrical Cardioversion
- Safe if Digoxin Level is under 2 ng/ml
- Use lowest possible energy if needed (10-20 J)
- Digibind (40 mg/vial)
Digitalis Toxicity (C0012254) | |
|---|---|
| Concepts | Injury or Poisoning (T037) |
| English | Digitalis Toxicity |
| Parent Concepts | Drug toxicity (C0013221) |
| Sources | COSTAR, MTH, NCI Derived from the NIH UMLS (Unified Medical Language System) |
Poisoning by digoxin (C0274727) | |
|---|---|
| Concepts | Injury or Poisoning (T037) |
| ICD9 | 972.1 |
| English | Digoxin poisoning, Digoxin toxicity, Poisoning by digoxin |
| Spanish | intoxicacion por digoxina, toxicidad por digoxina |
| Parent Concepts | Poisoning by cardiac rhythm regulator (C0412873), Poisoning by cardiotonic glycoside (C0412877) |
| Sources | MTHICD9, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
Digibind (C0687706) | |
|---|---|
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| MSH | C050199 |
| English | Digibind |
| Sources | MSH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
