II. Management: Specific Antidotes for AnalgesicOverdoses

III. Management: Specific Antidotes for cardiovascular agent Overdoses

IV. Management: Specific Antidotes for psychiatric agents

V. Management: Specific Antidotes for heavy metal and metal Overdoses

  1. Arsenic
    1. British Anti-Lewisite (BAL) Chelation or Dimercaprol
  2. Iron
    1. Deferoxamine (Desferal)
  3. Lead
    1. Dimercaptosuccinic acid (DMSA, Succimer or Chemet)
    2. Ethylenediaminetetraacetic acid (EDTA)
  4. Mercury
    1. Dimercaptosuccinic acid (DMSA, Succimer or Chemet)

VI. Management: Specific Antidotes for agents interfering with oxygenation

  1. Carbon Monoxide
    1. Oxygen
    2. Hyperbaric chamber
  2. Cyanide
    1. Nitrites (Cyanokit, Sodium nitrite, Sodium thiosulfate)
    2. Hydroxycobalamin (B12 analog)
    3. Oxygen
  3. Methemoglobinemia
    1. Methylene blue

VII. Management: Specific Antidotes for parasympathetic effects

VIII. Management: Specific Antidotes for miscellaneous Overdoses

  1. Fluoride
    1. Calcium
  2. Hydrazines
    1. Pyridoxine
  3. Isoniazid (INH)
    1. Pyridoxine
  4. Methanol or Ethylene Glycol
    1. Fomepizole (Antizol)
    2. Ethanol 10%
  5. Oxalates
    1. Calcium
  6. Hydrofluoric acid
    1. Calcium Gluconate
  7. Sulfonylurea
    1. See Sulfonylurea Overdose
    2. Octreotide (Sandostatin)
    3. Dextrose
    4. Glucagon (temporizing measure only)
  8. Valproic Acid
    1. Carnitine
  9. Warfarin
    1. Vitamin K
    2. Fresh Frozen Plasma
    3. Prothrombin Complex Concentrate 4 (PCC 4)

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