II. Background
- Sulfonylureas
- Sulfonylureas were first discovered in 1940's while investigating Sulfonamide antibiotics
- First Generation Sulfonylureas (e.g. Tolbutamide) were developed in the 1960s
- Second Generation Sulfonylureas were available in the 1980s
- Sulfonylureas are also used as herbicides (block specific plant Amino Acid biosynthesis)
-
Meglitinides
- Meglitinide development started in the 1970s and were marketed in the U.S. in the late 1990s
III. Mechanism
IV. Medications
- First Generation Sulfonylurea (Listed for historical purposes only)
- Second Generation Sulfonylurea (e.g. Glipizide, Glyburide)
- Non-Sulfonylurea Insulin Secretagogues (e.g. Meglitinide, Repaglinide)