II. Causes: Organophosphates

  1. Management: See Organophosphate Poisoning Management
  2. Mechanism
    1. Irreversibly inhibits cholinesterase
    2. Results in Cholinergic Toxicity
  3. Pesticides
    1. Acephate (Orthene)
    2. Chlorphoxim (Baythion-C)
    3. Chlorpyrifos (Dursban, Lorsban)
    4. Diazinon
    5. Dimethoate (Cygon, Defend)
    6. Ethoprop (Mocap)
    7. Fenitrothion (Sumithion)
    8. Fenthion (Baytex)
    9. Malathion (Cythion)
    10. Naled (Dibrome)
    11. Terbufos (Counter)
  4. Other Organophosphate agents
    1. Triorthocresyl phosphate (TOCP)
      1. Used in hydraulic fluids, lubricants, plastics
      2. May contaminate foods and result in Neuropathy

III. Causes: Carbamates

  1. Mechanism
    1. Reversible cholinesterase inhibition
    2. Results in Cholinergic Toxicity
      1. Less severe toxicity than with Organophosphates
  2. Management
    1. Similar to Organophosphate Poisoning Management
    2. 2-PAMCl not indicated unless mixed exposure
  3. Pesticides
    1. Carbaryl (Sevin)
    2. Primicarb (Aphox, Rapid)
    3. Propoxur (Baygon)
    4. Timethacarb (Landrin)

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Ontology: Carbamates (C0006948)

Definition (MSH) Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Definition (CSP) carbamic acid, its salts or esters; contains the general formula NH2-COO-.
Concepts Organic Chemical (T109)
MSH D002219
SnomedCT 79522001, 406748003
LNC LP19594-8, MTHU008703
Swedish Karbamater
Czech karbamáty, pentakain
Finnish Karbamaatit
Russian KARBAMATY, КАРБАМАТЫ
English Carbamates, Carbamates [Chemical/Ingredient], carbamates, carbamate, Carbamate, Carbamate (substance), Carbamates, NOS
Croatian Not Translated[Carbamates]
Polish Karbaminiany
Norwegian Not Translated[Carbamates]
Spanish carbamatos, carbamato (sustancia), carbamato, Carbamatos
French Carbamates
German Carbamate
Italian Carbammati
Portuguese Carbamatos

Ontology: Phosphoric Acid Esters (C0031701)

Definition (NCI_NCI-GLOSS) A form of phosphoric acid, which contains phosphorus. In the body, phosphates are found in the bones and teeth. Phosphates may be used to treat a high level of calcium in the blood. Adding or removing phosphate chemical groups may affect the way proteins act in the body.
Definition (NCI) An ester of phosphoric acid, which contains phosphorus. Organic phosphates play important roles in biochemistry and biogeochemistry or ecology.
Definition (MSH) Organic esters of phosphoric acid.
Definition (CSP) organic esters of phosphoric acid.
Concepts Organophosphorus Compound (T115)
MSH D010755
SnomedCT 50352000, 301785006
English Acid Esters, Phosphoric, Esters, Phosphoric Acid, Organic Phosphates, Phosphates, Organic, phosphoric ester, PHOSPHATES ORG, organophosphate, organic phosphates, organophosphates, organic phosphate, Organic Phosphate, Phosphoric Acid Esters, Organophosphates [Chemical/Ingredient], Organophosphates, phosphate, Organic phosphate, Organophosphate, Phosphoric acid ester, Phosphoric acid ester (substance), Organic phosphate, NOS, Organophosphate, NOS
Swedish Fosforsyraestrar
Finnish Fosforihappoesterit
Italian Fosfati organici, Esteri dell'acido fosforico
Japanese 有機リン酸塩, 有機リン酸, りん酸エステル, 有機りん酸塩, 燐酸エステル, リン酸エステル
Czech estery kyseliny fosforečné
French Phosphates organiques, Esters de l'acide phosphorique
German Phosphorsäureester, Phosphate, organische
Spanish Ésteres del Ácido Fosfórico, éster de ácido fosfórico (sustancia), éster de ácido fosfórico, Fosfatos Orgánicos
Portuguese Ésteres do Ácido Fosfórico, Fosfatos Orgânicos

Ontology: Organophosphate poisoning (C0700359)

Definition (MSH) Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.
Concepts Injury or Poisoning (T037)
MSH D062025
SnomedCT 88041008, 8260003, 71597002
English Organophosphate poisoning, Orgnphos insectcd caus tox eff, poisoning by organophosphorus insecticides (diagnosis), poisoning by organophosphorus insecticides, organophosphate poisoning, organophosphate poison, organophosphate toxicity, phosphate organic poisoning, organic phosphate poisoning, organophosphates poisoning, Organophosphate Poisonings, Poisoning, Organophosphate, Organophosphate Poisoning, Poisonings, Organophosphate, Organophosphate Poisoning [Disease/Finding], poisoning by organophosphate, poisoning by organophosphate insecticides (diagnosis), poisoning by organophosphate insecticides, Organophosphate intoxication, Organic phosphate poisoning, Organophosphate insecticide poisoning, Organophosphate toxicity, Organophosphate insecticide causing toxic effect, Organophosphate poisoning (disorder)
Czech otrava organofosfáty
French Empoisonnement par des organophosphates, Intoxication aux organophosphates, Intoxication par des organophosphates
German Organophosphatvergiftung, Organophosphat-Vergiftung
Italian Avvelenamento da organofosfati
Polish Zatrucie fosforanami organicznymi
Russian OTRAVLENIE ORGANICHESKIMI FOSFATAMI, ОТРАВЛЕНИЕ ОРГАНИЧЕСКИМИ ФОСФАТАМИ, ORGANOTIOFOSFONATAMI OTRAVLENIE, ОРГАНОТИОФОСФОНАТАМИ ОТРАВЛЕНИЕ, ORGANOFOSFATAMI OTRAVLENIE, FOSFORORGANICHESKIMI SOEDINENIIAMI OTRAVLENIE, ORGANOTIOFOSFATAMI OTRAVLENIE, ОРГАНОФОСФАТАМИ ОТРАВЛЕНИЕ, ФОСФОРОРГАНИЧЕСКИМИ СОЕДИНЕНИЯМИ ОТРАВЛЕНИЕ, ОРГАНОТИОФОСФАТАМИ ОТРАВЛЕНИЕ
Portuguese Intoxicação por Organofosfatos
Norwegian Organofosfatforgiftning
Spanish Intoxicación por Organofosfatos, Intoxicación por Organofosfato, intoxicación por fosfato orgánico, intoxicación por insecticida organofosforado, intoxicación por organofosforados (trastorno), intoxicación por organofosforados