Gastroenterology Book

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Alkaline Phosphatase

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  1. See Also
    1. Liver Function Test
    2. Liver Function Test Abnormality
  2. Normal: 30-120 U/L
  3. Increased
    1. Gastrointestinal Disease
      1. Bowel Disease
        1. Ulcerative Colitis
        2. Bowel perforation
      2. Hepatic Cholestasis
        1. Fatty Liver
        2. Alcoholic Hepatitis
        3. Benign or malignant liver tumor
        4. Primary biliary Cirrhosis
        5. Drug induced liver disease
        6. Hepatic granuloma
        7. Hepatic cyst
      3. Biliary Cholestasis
        1. Cholecystitis
        2. Cholelithiasis
        3. Primary Sclerosing Cholangitis
        4. Primary biliary Cirrhosis
    2. Bone disease
      1. Paget's Disease
      2. Osteitis Deformans
      3. Rickets
      4. Osteomalacia
      5. Bone Cancer or bone metastases
      6. Healing Fracture
    3. Endocrine disease
      1. Hypervitaminosis D
      2. Hyperparathyroidism
      3. Hyperthyroidism
      4. Acromegaly
    4. Infectious disease
      1. Epstein Barr Virus (EBV)
      2. Cytomegalovirus (CMV)
      3. Sepsis
    5. Medications
      1. Estrogens
        1. Estrogen Replacement Therapy
        2. Oral Contraceptives
      2. Albumin
      3. Erythromycin (and other antibiotics)
      4. Phenothiazines
    6. Other Causes
      1. Pulmonary infarction
      2. Congestive Heart Failure
      3. Leukemia
      4. Myelofibrosis
      5. Multiple Myeloma
  4. Decreased
    1. Hypothyroidism
    2. Pernicious Anemia
    3. Hypophosphatemia
    4. Hypervitaminosis D
    5. Poor nutrition

Alkaline Phosphatase (C0002059)

Definition (MSH)An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Definition (SPN)A leukocyte alkaline phosphatase test is a device used to identify the enzyme leukocyte alkaline phosphatase in neutrophilic granulocytes (granular leukocytes stainable by neutral dyes). The cytochemical identification of alkaline phosphatase depends on the formation of blue granules in cells containing alkaline phosphatase. The results of this test are used to differentiate chronic granulocytic leukemia (a malignant disease characterized by excessive overgrowth of granulocytes in the bone marrow) and reactions that resemble true leukemia, such as those occuring in severe infections and polycythemia (increased total red cell mass).
Definition (NCI)An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum.
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
EnglishAlkaline Phosphatase, alkaline phosphatases, Alkaline phosphomonoesterase, AP, Glycerophosphatase, Phosphomonoesterase
Spanishfosfatasa alcalina, fosfomonoesterasa, fosfomonoesterasa alcalina, glicerofosfatasa
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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