Rheumatology Book

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Osteomalacia

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  1. See Also
    1. Rickets (defective bone calcification in children)
  2. Definition
    1. Defective calcification of bone matrix in adults
  3. Pathophysiology
    1. Defective bone calcification after growth plates close
    2. Associated with increased Osteoblast activity
  4. Causes
    1. Vitamin D Deficiency
    2. Renal Tubular Acidosis (Vitamin D-Resistant)
  5. Symptoms
    1. Anorexia and weight loss
    2. Muscle Weakness
    3. Bone pain
  6. Signs
    1. Skull, spine and pelvis with deformities
    2. See Vitain D Deficiency
  7. Radiology
    1. Pseudofractures (Looser's Zones)
      1. Radiolucent defects of skull, spine and pelvis
      2. Transverse lines in bony cortex
    2. Vertebral Fractures
  8. Management
    1. See Vitamin D Deficiency
  9. References
    1. Drezner in Goldman (2004) Cecil Medicine, p. 1555-62
    2. Lane in Harris (2005) Kelly's Rheumatology, p. 1485-7

Osteomalacia (C0029442)

Definition (MSH)A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (Dorland, 27th ed)
Definition (CSP)inadequate or delayed mineralization of osteoid in mature cortical and spongy bone.
Definition (NCI)A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003
ConceptsDisease or Syndrome (T047)
ICD9268.2
MSHD010018
EnglishOM - Osteomalacia, Osteomalacia, Osteomalacia unspecified, Osteomalacias
Spanishosteomalacia, osteomalacia no especificada
Parent Conceptsosteopathy, chondropathy, acquired deformity (C0679391), Bone Diseases, Metabolic (C0005944), Vitamin D Deficiency (C0042870), CALCIUM DISORDER (C0302590), Disorder of skeletal system (C0263661), Bone Disorders, General and NEC (C0549572), CALCIUM/PHOSPHATE ABNORMALITY (C0549633), Calcium Metabolism Disorders (C0006705), Non-Neoplastic Bone Disorder (C1334997), Osteomalacia (C0029442), Degenerative disorder (C1285162), Disorder with defective osteoid mineralization (C1290193)
SourcesAOD, COSTAR, CSP, CST, DXP, ICD9CM, LCH, MSH, NCI, NDFRT, OMIM, QMR, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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