Rheumatology Book

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Osteomalacia

Aka: Osteomalacia
  1. See Also
    1. Rickets (defective bone calcification in children)
  2. Definition
    1. Defective calcification of bone matrix in adults
  3. Pathophysiology
    1. Defective bone calcification after Growth Plates close
    2. Associated with increased Osteoblast activity
  4. Causes
    1. Vitamin D Deficiency
    2. Renal Tubular Acidosis (Vitamin D-Resistant)
  5. Symptoms
    1. Anorexia and weight loss
    2. Muscle Weakness
    3. Bone pain
  6. Signs
    1. Skull, spine and Pelvis with deformities
    2. See Vitain D Deficiency
  7. Radiology
    1. Pseudofractures (Looser's Zones)
      1. Radiolucent defects of skull, spine and Pelvis
      2. Transverse lines in bony cortex
    2. Vertebral Fractures
  8. Management
    1. See Vitamin D Deficiency
  9. References
    1. Drezner in Goldman (2004) Cecil Medicine, p. 1555-62
    2. Lane in Harris (2005) Kelly's Rheumatology, p. 1485-7

Osteomalacia (C0029442)

Definition (NCI) A condition in adults in which bones become soft and deformed because they don't have enough calcium and phosphorus. It is usually caused by not having enough vitamin D in the diet, not getting enough sunlight, or a problem with the way the body uses vitamin D. Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets.
Definition (MSH) A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (Dorland, 27th ed)
Definition (CSP) inadequate or delayed mineralization of osteoid in mature cortical and spongy bone.
Definition (NCI) A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003
Concepts Disease or Syndrome (T047)
MSH D010018
ICD9 268.2
SnomedCT 190642003, 4598005, 154728003, 190639009
English Osteomalacias, OSTEOMALACIA, Osteomalacia unspecified, Osteomalacia, unspecified, osteomalacia, osteomalacia (diagnosis), Adult rickets, Osteomalacia NOS, Osteomalacia unspecified (disorder), Osteomalacia [Disease/Finding], adults rickets, adult rickets, Osteomalacia, OM - Osteomalacia, Osteomalacia (disorder), malacia; bone
French OSTEOMALACIE, Rachitisme adulte, Ostéomalacie non précisée, Ostéomalacie
Portuguese OSTEOMALACIA, Raquitismo do adulto, Osteomalacia NE, Osteomalacia
Spanish OSTEOMALACIA, Osteomalacia no especificada, Raquitismo del adulto, Osteomalacia, osteomalacia (trastorno), osteomalacia no especificada (trastorno), osteomalacia no especificada, osteomalacia
German OSTEOMALAZIE, Osteomalazie, unspezifisch, Rachitis beim Erwachsenen, Osteomalazie
Dutch rachitis in volwassene, niet-gespecificeerde osteomalacie, malacie; bot, osteomalacie, Malacie, osteo-, Osteomalacie
Italian Rachitismo dell'adulto, Osteomalacia non specificata, Osteomalacia
Japanese 成人性くる病, 骨軟化症、詳細不明, 骨軟化症, ｾｲｼﾞﾝｾｲｸﾙﾋﾞｮｳ, ｺﾂﾅﾝｶｼｮｳ, ｺﾂﾅﾝｶｼｮｳｼｮｳｻｲﾌﾒｲ
Swedish Benvävsuppmjukning
Czech osteomalacie, Osteomalacie, Osteomalacie, blíže neurčená, Rachitida dospělých, měknutí kostí
Finnish Osteomalasia
Russian OSTEOMALIATSIIA, ОСТЕОМАЛЯЦИЯ
Polish Osteomalacja
Hungarian Felnőttkori rachitis, Osteomalacia, Osteomalacia, nem meghatározott
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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