Nephrology Book

Abnormally Increased

Abnormally Decreased

  • Hypophosphatemia

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Hypophosphatemia

Aka: Hypophosphatemia, Low Serum Phosphorus
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  1. Causes
    1. Starvation
    2. Diabetic Ketoacidosis
    3. Total Parenteral Nutrition (TPN)
    4. Insulin
    5. Nasogastric Suction (NG Suction)
    6. Diuretics
    7. Vomiting
    8. Vitamin D Deficiency
    9. Hypoparathyroid
    10. Pseudohypoparathyroidism
    11. Medications
      1. Corticosteroids
      2. Aluminum Hydroxide antacids
    12. Gram NegativeSepsis
  2. Evaluation
    1. Check Urinary Phosphate excretion (Urine pHosphorus)
    2. Low Urine pHosphorus: under 100 mg/d (FePO4 under 10%)
      1. Internal Redistribution
        1. Glucose administration
        2. Alkalosis
        3. DKA recovery
      2. Gastrointestinal Losses
        1. Malabsorption
        2. Vomiting
        3. Diarrhea
        4. Aluminum or Magnesium antacids
    3. High Urine pHosphorus: over 100mg/d (FePO4 over 20%)
      1. Check for wasting in urine of other electrolytes
        1. Glucose
        2. Amino acid
        3. Uric Acid
        4. Bicarbonate
      2. Electrolyte Wasting present
        1. Fanconi's Syndrome
          1. Idiopathic
          2. Sporadic
          3. Familial
        2. Cystinosis
        3. Amyloidosis
        4. Multiple Myeloma
        5. Wilson's Disease
        6. Nephrotic Syndrome
        7. Cadmium toxicity
        8. Acute Lead Toxicity
      3. Electrolyte Wasting absent
        1. Increased Serum Calcium
          1. Primary or ectopic Hyperparathyroidism
        2. Normal or Low Serum Calcium
          1. Secondary Hyperparathyroidism
          2. Androgen or Estrogen treatment
          3. Thiazide Diuretics
          4. Vitamin D resistant Rickets
          5. Post Acute Tubular Necrosis
          6. Post-transplant
  3. Management
    1. See Phosphorus Replacement

Hypophosphatemia (C0085682)

Definition (NCI) Lower than normal levels of phosphates in the circulating blood.
Definition (NCI) A disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.
Definition (CSP) abnormally decreased amounts of phosphates in the blood; manifestations include hemolysis, lassitude, weakness, and convulsions.
Definition (MSH) A condition of an abnormally low level of PHOSPHATES in the blood. Severe hypophosphatemia (below 1 mg/liter) can affect every organ in the body leading to HEMOLYSIS; LASSITUDE; SEIZURES; and COMA. Chronic hypophosphatemia can lead to MUSCLE WEAKNESS; and bone diseases, such as RICKETS and OSTEOMALACIA.
Concepts Pathologic Function (T046)
MSH D017674
SnomedCT 4996001
English Hypophosphatemia, HYPOPHOSPHATAEMIA, Hypophosphatemias, HYPOPHOSPHATEMIA, Hypophosphatemia, NOS, Hypophosphataemia, NOS, hypophosphatemia, hypophosphatemia (diagnosis), Hypophosphatemia [Disease/Finding], disorder hypophosphatemia, hypophosphataemia, Hypophosphataemia, Hypophosphatemia (disorder)
French HYPOPHOSPHATEMIE, Hypophosphatémie
Portuguese HIPOFOSFATEMIA, Hipofosfatemia
Spanish HIPOFOSFATEMIA, hipofosfatemia (trastorno), hipofosfatemia, Hipofosfatemia
German HYPOPHOSPHATAEMIE, Hypophosphataemie, Hypophosphatäme
Japanese 低リン酸血症, テイリンサンケツショウ, テイリンサンケッショウ
Swedish Hypofosfatemi
Czech hypofosfatémie, Hypofosfatemie
Finnish Hypofosfatemia
Russian GIPOFOSFATEMIIA, ГИПОФОСФАТЕМИЯ
Croatian HIPOFOSFATEMIJA
Polish Hipofosfatemia
Hungarian Hypophosphataemia
Dutch hypofosfatemie, Fosfatemie, hypo-, Hypofosfatemie
Italian Ipofosfatemia
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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