Endocrinology Book

http://www.fpnotebook.com/

Acromegaly

Advertisement

  1. See Also
    1. Gigantism
  2. Pathophysiology
    1. Pituitary adenoma hypersecretion of Growth Hormone
    2. Occurs after closure of epiphyses
  3. Causes
    1. Hyperplastic pituitary adenoma
    2. Eosinophilic pituitary adenoma
  4. Symptoms
    1. Headache
    2. Vision loss
    3. Muscular weakness
    4. Back pain
    5. Limb pain
    6. Sweating
    7. Amenorrhea
    8. Polydipsia
    9. Polyuria
  5. Signs
    1. Exaggerated supraorbital ridges
    2. Exophthalmos
    3. Enlargement of:
      1. Hands and Feet
      2. Mandible (separation of teeth)
      3. Nose, Lips and Tongue
    4. Bitemporal hemianopsia to blindness
    5. Weight gain
    6. Hypertension
    7. Cardiomegaly
    8. Hepatomegaly
    9. Hypertrichosis
    10. Hyperthyroidism
      1. Goiter
      2. Thyrotoxicosis
    11. Diabetes Insipidus
  6. Radiology
    1. Overgrowth of cancellous bone
    2. Osteoporosis
    3. Tufted phalangeal tips
    4. Osteoarthritis signs
    5. Enlarged sella turcica
  7. Labs
    1. Elevated plasma Growth Hormone (in active stage)
    2. Increased urinary 17-ketosteroids
    3. High serum inorganic Phosphate
    4. Elevated Alkaline Phosphatase
    5. Hyperglycemia
    6. Glycosuria
  8. Management
    1. Transphenoidal surgery
    2. Radiation Therapy
    3. Bromocriptine

Acromegaly (C0001206)

Definition (AIR)WHAT: Acromegaly: Hypersecretion of growth hormone from a pituitary tumor resulting in insidious increase in the skeleton, soft tissues and organs. WHY: Acromegaly can result in an arthropathy with initial cartilage hypertrophy resulting in widening of the cartilage space on radiographs. The cartilage then undergoes premature osteoarthritis change with productive bony change characterized by broad distal tufts in the phalanges.
Definition (MSH)A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Definition (CSP)disorder caused by excessive secretion of somatotropin, characterized by bony enlargement of face, hands, feet, head and thorax.
ConceptsDisease or Syndrome (T047)
EnglishAcromegalia, Acromegaly, Anterior pituitary adenoma syndrome, Growth hormone hypersecretion syndrome, INAPPROPRIATE GH SECRET SYNDROME ACROMEGALY, INAPPROPRIATE GROWTH HORMONE SECRET SYNDROME ACROMEGALY, Marie disease, SOMATOTROPIN HYPERSECRET SYNDROME ACROMEGALY, STH hypersecretion syndrome
Spanishacromegalia, enfermedad de Marie, hipersecrecion de STH, sindrome de adenoma hipofisario anterior, sindrome de hipersecrecion de somatotrofina, sindrome de hipersecrecion de somatotropina
Parent ConceptsFormer or Present Systemic Disease (C0150840), Concomitant or past diseases (C0150941), Rheumatic illness with extraarticular and/or constitutional features (fever, rash, pleurisy,etc) OR Systemic illness with rheumatic manifestation (C0221589), Hyperpituitarism (C0020506), Bone Diseases, Developmental (C0005941), Bone Diseases, Endocrine (C0005942), Gigantism and acromegaly (C0405578)
SourcesAIR, AOD, COSTAR, CSP, DXP, LCH, MEDLINEPLUS, MSH, MTH, NDFRT, OMIM, QMR, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree