Endocrinology Book

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GoiterAka: Simple Goiter, Endemic Goiter, Colloid Goiter

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  1. Epidemiology
    1. Endemic in areas distant from sea (e.g. mountains)
      1. Common sites: Alps, Andes, and Himalayas
      2. Related to deficient iodine intake
      3. Often occurs before Puberty
    2. Sporadic form much more common in women (8:1)
      1. Adolescent girls
      2. Pregnant, Lactating or Menopausal women
  2. Criteria
    1. Diffuse Thyroid enlargement without nodularity
    2. Euthyroid function
  3. Causes
    1. Idiopathic (Sporadic)
    2. Iodine Deficiency (Endemic Goiter)
    3. Goitrogens (Thyroid suppressants)
      1. Calcium and fluorides in water
      2. Cabbage
      3. Cassava
      4. Cauliflower
      5. Brussels sprouts
      6. Turnips
  4. Symptoms
    1. Often asymptomatic
    2. Thyroid sensitive to touch
    3. Dyspnea
    4. Dysphagia
    5. Cough with large glands
  5. Signs
    1. Palpable diffuse Thyroid enlargement
    2. No Thyroid nodularity
  6. Management
    1. Early Goiter
      1. Iodine replacement results in goiter regression
    2. Late Goiter
      1. Thyroid Replacement required
  7. Prevention
    1. Iodized salt in diet
  8. Course
    1. If untreated, develops into Multinodular Goiter
  9. References
    1. Rifat (1994) Am Fam Physician 50(4):785
    2. Siminoski (1995) JAMA 273(10):813

Goiter (C0018021)

Definition (MSH)Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Definition (CSP)enlargement of the thyroid gland.
Definition (NCI)An enlarged thyroid. It may be caused by too little iodine in the diet or by other conditions. Most goiters are not cancer.
ConceptsDisease or Syndrome (T047)
ICD9240.9, 240.9
MSHD006042
EnglishEnlargement of thyroid, Form of goiter, Form of goitre, Goiter, Goiters, GOITRE, Struma - goiter, Struma - goitre, Struma of thyroid, Swelling of thyroid gland, THYROID ENLARGED, Thyroid enlargement, THYROMEGALY
NorwegianSTRUMA/THYR KNUTE U/HYPERTYREOSE
Spanishagrandamiento de la tiroides, bocio, estruma tiroideo, forma del bocio
SwedishSTRUMA
Parent ConceptsThyroid Diseases (C0040128), Thyroid dysfunction (C0348024), Simple and unspecified goiter (C0037158), ENDOCRINE, METABOLIC AND NUTRITIONAL (C0497395), Diagnosis/Diseases Component (C0497531), Non-Neoplastic Endocrine Disorder (C1335007), Non-Neoplastic Thyroid Gland Disorder (C1335047), Goiter (C0018021), Form of lesion (C0449596), Duplicate concept (C1274013)
SourcesAOD, COSTAR, CSP, CST, DXP, ICD9CM, ICPC, ICPCBAQ, ICPCDAN, ICPCDUT, ICPCFIN, ICPCFRE, ICPCGER, ICPCHEB, ICPCHUN, ICPCITA, ICPCNOR, ICPCPOR, ICPCSPA, ICPCSWE, LCH, MEDLINEPLUS, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Endemic goiter (C0018022)

Definition (MSH)A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.
ConceptsDisease or Syndrome (T047)
ICD9240.0
MSHD006043
EnglishEndemic goiter, Endemic Goiters, Endemic goitre, GOITER ENDEMIC, Iodine-deficiency-related endemic goiter, Iodine-deficiency-related endemic goitre, MNG1, Simple goiter, Simple goitre, Simple iodine deficiency goiter, Simple iodine deficiency goitre
Spanishbocio endemico, bocio endemico relacionado con deficiencia de yodo, bocio simple, bocio simple por deficiencia de yodo
Parent ConceptsSimple and unspecified goiter (C0037158), Goiter (C0018021), Endemic goiter (C0018022), Thyroid Diseases (C0040128), Iodine deficiency syndrome (C0342199), Duplicate concept (C1274013)
SourcesCOSTAR, DXP, ICD9CM, MSH, MTH, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Colloid goiter (C0221268)

ConceptsDisease or Syndrome (T047)
EnglishColloid goiter, Colloid goitre, Non-toxic colloid goiter, Non-toxic colloid goitre, Non-toxic diffuse colloid goiter, Non-toxic diffuse colloid goitre
Spanishbocio coloide
Parent ConceptsEndemic goiter (C0018022)
SourcesDXP, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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