Endocrinology Book

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Goiter

Aka: Goiter, Simple Goiter, Endemic Goiter, Colloid Goiter
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  1. Epidemiology
    1. Endemic in areas distant from sea (e.g. mountains)
      1. Common sites: Alps, Andes, and Himalayas
      2. Related to deficient iodine intake
      3. Often occurs before Puberty
    2. Sporadic form much more common in women (8:1)
      1. Adolescent girls
      2. Pregnant, Lactating or Menopausal women
  2. Criteria
    1. Diffuse Thyroid enlargement without nodularity
    2. Euthyroid function
  3. Causes
    1. Idiopathic (Sporadic)
    2. Iodine Deficiency (Endemic Goiter)
    3. Goitrogens (Thyroid suppressants)
      1. Calcium and fluorides in water
      2. Cabbage
      3. Cassava
      4. Cauliflower
      5. Brussels sprouts
      6. Turnips
  4. Symptoms
    1. Often asymptomatic
    2. Thyroid sensitive to touch
    3. Dyspnea
    4. Dysphagia
    5. Cough with large glands
  5. Signs
    1. Palpable diffuse Thyroid enlargement
    2. No Thyroid nodularity
  6. Management
    1. Early Goiter
      1. Iodine replacement results in Goiter regression
    2. Late Goiter
      1. Thyroid Replacement required
  7. Prevention
    1. Iodized salt in diet
  8. Course
    1. If untreated, develops into Multinodular Goiter
  9. References
    1. Rifat (1994) Am Fam Physician 50(4):785-90
    2. Siminoski (1995) JAMA 273(10):813-7

Endemic goiter (C0018022)

Definition (MSH) A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.
Concepts Disease or Syndrome (T047)
MSH D006043
ICD9 240.0
ICD10 E01.2, E01.0
SnomedCT 190319000, 190316007, 191043000, 267369002, 56805008, 271949009, 190234009
English Endemic Goiters, Goiter, Endemic, Goiters, Endemic, Goiter, specified as simple, GOITER ENDEMIC, Goiter, endemic, Iodine goiter, Endemic goiter, Endemic goiter - iodine defic, Endemic goitre - iodine defic, Iod-def-rel (endm) goit,uns, Iod-def-reltd df(endemic)goitr, Iodine-deficiency-related (endemic) goiter, unspecified, Iodine-deficiency-related (endemic) goitre, unspecified, [X]Iod-def-rel (endm) goit,uns, [X]Iodine-deficiency-related (endemic) goiter, unspecified, [X]Iodine-deficiency-related (endemic) goitre, unspecified, simple goiter (diagnosis), iodine deficient endemic goiter, iodine deficient endemic goiter (diagnosis), simple goiter, [X]Iodine-deficiency-related (endemic) goitre, unspecified (disorder), Iodine-deficiency-related endemic goitre (disorder), Goitre, specified as simple, [X]Iodine-deficiency-related (endemic) goiter, unspecified (disorder), Endemic goiter NOS, Iodine-deficiency related diffuse (endemic) goiter, Iodine-deficiency related (endemic) goiter, unspecified, Goiter, Endemic [Disease/Finding], endemic goiter, goiters iodine, iodine goiter, endemic goitre, Simple goiter, Simple iodine deficiency goiter, Endemic goitre, Iodine-deficiency-related diffuse (endemic) goiter, Iodine-deficiency-related diffuse (endemic) goitre, Simple goitre, Simple iodine deficiency goitre, Iodine-deficiency-related endemic goiter, Iodine-deficiency-related endemic goitre, Endemic goiter (disorder), Iodine-deficiency-related endemic goiter (disorder), Simple goiter (disorder), endemic; goiter, iodine-deficiency; goiter (endemic), simple; goiter, struma; endemic, struma; iodine-deficiency (endemic), struma; simple, Simple Goiter, Endemic Goiter
Dutch struma, gespecificeerd als enkelvoudig, enkelvoudige struma, endemisch struma, endemisch; struma, jodiumdeficiëntie; struma (endemisch), simplex; struma, struma; endemisch, struma; jodiumdeficiëntie (endemisch), struma; simplex, Diffuse (endemische) struma samenhangend met jodiumdeficiëntie, Struma (endemisch) samenhangend met jodiumdeficiëntie, niet gespecificeerd, Endemische struma, Struma, endemisch
French Goitre, précisé simple, Goitre simple, Goitre endémique
German Struma, als einfach bezeichnet, einfache Struma, Jodmangelbedingte Struma (endemisch), nicht naeher bezeichnet, Jodmangelbedingte diffuse Struma (endemisch), endemischer Kropf, Struma, endemische
Italian Gozzo specificato come semplice, Gozzo semplice, Gozzo endemico
Portuguese Bócio especificado como simples, Bócio simples, Bócio endémico, Bócio Endêmico
Spanish Bocio especificado como simple, Bocio simple, [X]Iodine-deficiency-related (endemic) goitre, unspecified, Iodine-deficiency-related endemic goiter, Iodine-deficiency-related endemic goitre, [X]Iodine-deficiency-related (endemic) goiter, unspecified, Simple goiter, Simple goitre, [X]bocio relacionado con la deficiencia de iodo (endémico), no especificado, [X]bocio relacionado con la deficiencia de yodo (endémico), no especificado, [X]bocio relacionado con la deficiencia de yodo (endémico), no especificado (trastorno), Bocio endémico, bocio endémico (trastorno), bocio endémico relacionado con deficiencia de yodo (trastorno), bocio endémico relacionado con deficiencia de yodo, bocio endémico, bocio simple (trastorno), bocio simple por deficiencia de yodo, bocio simple, Bocio Endémico, Bocio Endemico
Japanese 単純性甲状腺腫, ﾀﾝｼﾞｭﾝｾｲｺｳｼﾞｮｳｾﾝｼｭ, 甲状腺腫-地方病性, ﾁﾎｳﾋﾞｮｳｾｲｺｳｼﾞｮｳｾﾝｼｭ, 地方性甲状腺腫, 地方病性甲状腺腫
Swedish Struma, endemisk
Czech struma endemická, Struma, určená jako prostá, Prostá struma, Endemická struma
Finnish Endeeminen struuma
Russian ZOB ENDEMICHESKII, ЗОБ ЭНДЕМИЧЕСКИЙ
Korean 요오드결핍과 관련된 미만성(풍토성) 갑상샘종, 요오드결핍과 관련된(풍토성) 상세불명의 갑상샘종
Croatian STRUMA, ENDEMSKA
Polish Wole endemiczne
Hungarian Struma, egyszerűnek meghatározott, Endemiás struma, Egyszerű struma
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Goiter (C0018021)

Definition (NCI) Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.
Definition (MSH) Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).
Definition (CSP) enlargement of the thyroid gland.
Definition (NCI) An enlarged thyroid. It may be caused by too little iodine in the diet or by other conditions. Most goiters are not cancer.
Concepts Disease or Syndrome (T047)
MSH D006042
ICD9 240.9
ICD10 E04.9
SnomedCT 237568003, 267370001, 3716002, 190235005, 190232008
English Enlarged thyroid gland, GOITER, GOITRE, THYROID ENLARGED, THYROID ENLARGEMENT, THYROMEGALY, Goiter, NOS, Goitre, NOS, Goiter NOS, Goiter, unspecified, Goitre NOS, Goiter (excl T85 T86), Goiter (excluding T85 T86), thyromegaly, Goitre (disorder), enlargement under Adam's apple (symptom), enlargement under Adam's apple, goiter, Goiter, Enlarged thyroid, Thyroid enlarged, Goitre, unspecified, THYROID GOITER, Goiter NOS (disorder), Goiter [Disease/Finding], enlargement of thyroid, swelling thyroid gland, Enlarged;thyroid, Enlargement;thyroid, goiter thyroid, thyroid goiter, Struma, enlarged thyroid gland, goitres, goiters, thyroid gland swelling, Thyromegaly, Enlargement of thyroid, Struma of thyroid, Goitre, Struma - goiter, Struma - goitre, Swelling of thyroid gland, Thyroid enlargement, Goiter (disorder), enlargement; thyroid, struma, thyroid; enlargement, Goiters, enlarged thyroid, goitre, thyroid enlargement
French GOITRE, Goitre, non précisé, Hypertrophie thyroïdienne, Goitre non précisé, Thyromégalie, AUGMENTATION VOLUME THYROIDE, Goitre (SF T85 T86), Goitre
Portuguese BOCIO, Bócio NE, Tiroideia aumentada de volume, Tiromegalia, AUMENTO DE VOLUME DA TIROIDE, Bocio (excl T85 T86), Bócio
Spanish BOCIO, Bocio no especificado, Tiromegalia, Hipertrofia del tiroides, Tiroides agrandado, Thyroid enlargement, Struma - goitre, Goitre, Goiter NOS, Struma - goiter, Goitre NOS, Goiter, Bocio/nodulo (ex T85 T86), TIROIDES AUMENTADO, agrandamiento de la tiroides, bocio (trastorno), bocio, SAI (trastorno), bocio, SAI, bocio, estruma tiroideo, Bocio
German STRUMA, Struma, unspezifisch, vergroesserte Schilddruese, Schilddruesenvergroesserung, Schilddruese vergroessert, SCHILDDRUESENVERGROESSERG, Struma (ex T85 T86), Kropf, Struma
Dutch struma, niet-gespecificeerd, thyromegaly, vergroot thyroïd, vergrote schildklier, Struma (ex T85 T86), schildklier; vergroting, vergroting; schildklier, struma, Goitre, Krop, Struma
Italian Gozzo non specificato, Tiroide ingrandita, Tiromegalia, Gozzo(escl T85 T86), Gozzo
Japanese 甲状腺腫、詳細不明, 甲状腺腫大, 甲状腺腫, ｺｳｼﾞｮｳｾﾝｼｭｼｮｳｻｲﾌﾒｲ, ｺｳｼﾞｮｳｾﾝｼｭﾀﾞｲ, ｺｳｼﾞｮｳｾﾝｼｭ
Swedish Struma, STRUMA
Czech struma, Struma, blíže neurčená, Zvětšená štítná žláza, Tyromegalie, Struma
Finnish Struuma, STRUUMA (PL T85,T86)
Russian ZOB, ЗОБ
Norwegian STRUMA/THYR KNUTE U/HYPERTYREOSE
Danish Struma/knude tyreoidea (ex T85 T86)
Hungarian golyva (kiv. T85, T86), Struma, Struma, nem meghatározott, Pajzsmirigy megnagyobbodása, Pajzsmirigy-megnagyobbodás, Megnagyobbodott pajzsmirigy
Croatian STRUMA
Basque BOZIOA,TIROTOSIKOSI GABEKO NODULO TIROIDEA
Hebrew hagdalat hatiroid, goiter lelo yeter peilut
Polish Wole
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Colloid goiter (C0221268)

Concepts Disease or Syndrome (T047)
ICD10 E04.0
SnomedCT 61037007, 190234009
English GOITER, COLLOID, Goiter, colloid, Non-tox diffus colloid goiter, Non-tox diffus colloid goitre, Diffuse (colloid) nontoxic goiter, colloid goitre, colloid goiter, goiter colloid, Colloid goiter, Colloid goitre, Non-toxic diffuse colloid goiter, Non-toxic diffuse colloid goitre, Non-toxic colloid goiter, Non-toxic colloid goitre, Colloid goiter (disorder), nontoxic; goiter, diffuse (colloid), struma; nontoxic, diffuse (colloid)
Spanish Colloid goiter, Colloid goitre, bocio coloide (trastorno), bocio coloide
Dutch niet-toxisch; struma, diffuus (colloïd), struma; niet-toxisch, diffuus (colloïd)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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