I. See Also

II. Pathophysiology

  1. Eosinophilic Pituitary Adenoma
  2. Results in hypersecretion of Growth Hormone
  3. Occurs in children before epiphyseal closure
    1. Results in excessive growth
    2. Contrast with Acromegaly in adults

III. Symptoms

  1. Rapid excessive growth
  2. Weakness

IV. Signs

  1. Excessive lengthening of bones
  2. Normal body proportions
  3. Increased Intracranial Pressure
  4. Diffuse organ hyperplasia

V. Radiology

  1. XRay Sinuses
    1. Frontal Sinuses enlarged
  2. XRay Hand
    1. Tufting of distal phalanges
    2. Metacarpal broadening
  3. XRay Spine
    1. Vertebral broadening
  4. XRay Mandible
    1. Hyperplasia of the Mandible
  5. CT Head
    1. Sella turcica widening

Images: Related links to external sites (from Google)

Ontology: Gigantism (C0017547)

Definition (NCI) A clinical finding indicating abnormal and excessive body growth and height resulting from the overproduction of human growth hormone.
Definition (NCI) A condition in which the whole body or any of its parts grow much larger than normal.
Definition (CSP) condition of abnormal overgrowth or excessive size of the whole body or any of its parts.
Definition (MSH) The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Concepts Disease or Syndrome (T047)
MSH D005877
SnomedCT 123111004, 80849007, 86073008, 363094008, 154698000, 267480001
English Gigantism, GIGANTISM, GIGANTISM, PITUITARY, Giant, NOS, Giant, genetic, Giantism, NOS, Gigantism, NOS, Gigantosoma, gigantism (diagnosis), gigantism, gigantism (physical finding), Giant (disorder), gigantism was noted, Gigantism [Disease/Finding], giant, giantism, gigantism disorder, genetics giant, giants, Giant, Pituitary gigantism, Genetic giant, Normal giant, Primordial giant, Disorders with tall stature (disorder), Disorders with tall stature, Giantism, Gigantism (disorder), gigantism; pituitary, pituitary; gigantism, Giant -RETIRED-, Gigantism, Pituitary, Pituitary Gigantism
French GIGANTISME, Gigantisme, Gigantisme hypophysaire
Portuguese GIGANTISMO, Gigantismo
Spanish GIGANTISMO, trastornos relacionados con talla alta, Gigantism, gigante (concepto no activo), gigante genético, gigante normal, gigante primordial, gigante, gigantismo (trastorno), gigantismo, trastornos asociados con estatura elevada (trastorno), trastornos asociados con estatura elevada, trastornos relacionados con talla alta (trastorno), Gigantismo
German GIGANTISMUS, Gigantismus
Swedish Jätteväxt
Japanese キョジンショウ, 巨人症
Czech gigantismus, Gigantismus
Finnish Jättikasvu
Russian MAKROSOMIIA, GIGANTIZM, ГИГАНТИЗМ, МАКРОСОМИЯ
Italian Gigantismo pituitario, Gigantismo
Croatian GIGANTIZAM, DIVOVSKI RAST, ORIJAŠKI RAST
Polish Gigantyzm
Hungarian Gigantizmus
Dutch gigantisme; hypofyse, hypofyse; gigantisme, gigantisme, Gigantisme, Reuzengroei