Endocrinology Book

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Gigantism

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  1. See Also
    1. Acromegaly
  2. Pathophysiology
    1. Eosinophilic pituitary adenoma
    2. Results in hypersecretion of Growth Hormone
    3. Occurs in children before epiphyseal closure
      1. Results in excessive growth
      2. Contrast with Acromegaly in adults
  3. Symptoms
    1. Rapid excessive growth
    2. Weakness
  4. Signs
    1. Excessive lengthening of bones
    2. Normal body proportions
    3. Increased Intracranial Pressure
    4. Diffuse organ hyperplasia
  5. Radiology
    1. XRay Sinuses
      1. Frontal sinuses enlarged
    2. XRay Hand
      1. Tufting of distal phalanges
      2. Metacarpal broadening
    3. XRay Spine
      1. Vertebral broadening
    4. XRay Mandible
      1. Hyperplasia of the mandible
    5. CT Head
      1. Sella turcica widening

Gigantism (C0017547)

Definition (MSH)The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Definition (CSP)condition of abnormal overgrowth or excessive size of the whole body or any of its parts.
ConceptsDisease or Syndrome (T047)
MSHD005877
EnglishAnterior pituitary hyperfunction, Disorders with tall stature, Genetic giant, Giant, Giant -RETIRED-, Giantism, Gigantism, Normal giant, Pituitary gigantism, Primordial giant
Spanishgigante, gigante genetico, gigante normal, gigante primordial, gigantismo, trastornos asociados con estatura elevada, trastornos relacionados con talla alta
Parent ConceptsBone Diseases, Developmental (C0005941), Hyperpituitarism (C0020506), Growth Disorders NEC (C0549569), HYPOTHALMIC/PITUITARY (C0549611), Bone Diseases, Endocrine (C0005942), Disorder of stature (C0342570), Gigantism and acromegaly (C0405578), Reason not stated concept (C1276325)
SourcesCSP, CST, DXP, MSH, MTH, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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