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Thyroxine Binding GlobulinAka: Thyroid Binding Globulin, TBG
- Physiology
- Radioimmunoassay of major storage of Thyroid hormone
- TBG binds Thyroid hormone in circulation
- Thyroxine (T4) is 99.97% protein bound
- Triiodothyronine (T3) is 99.7% protein bound
- Interpretation
- TBG effects measurement of total T4 and T3
- Labs unaffected by Thyroid Binding Globulin (TBG)
- Free Thyroxine Index (FTI)
- Calculation based on T3 Resin Uptake
- Free Thyroxine (Free T4)
- Free Triiodothyronine (Free T3)
- Free Thyroxine Index (FTI)
- Increased TBG (Reduces total T4 and T3 measurements)
- Pregnancy
- Newborn state
- Chronic Active Hepatitis
- Biliary Cirrhosis
- Infection
- Acute intermittent porphyria
- Familial hyperthyroxinemia
- Drugs
- Oral Contraceptives
- Estrogens
- Tamoxifen
- Methadone
- Heroin
- Perphenazine
- Decreased TBG (Elevates total T4 and T3 measurements)
- Chronic Liver Disease
- Obstructive Jaundice or Cirrhosis
- Severe systemic illness
- Active Acromegaly
- Nephrotic Syndrome
- Surgical Stress
- Medications
- Androgens
- Salicylates
- L-asparaginase
- Large doses of glucocorticoids (Prednisone)
Thyroxine-Binding Globulin (C0087090) | |
|---|---|
| Concepts | Amino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123) |
| English | TBG, Thyroxin-binding globulin, Thyroxine binding glob., Thyroxine binding globulin, Thyroxine binding globulin -RETIRED-, Thyroxine binding globulin-TBG, Thyroxine-Binding Globulin |
| Spanish | globulina fijadora de T4, globulina fijadora de tiroxina, globulina fijadora de tiroxina - RETIRADO - |
| Parent Concepts | Serpins (C0036764), Binding Protein (C0242210), Ambiguous concept (C1274012) |
| Sources | LNC, MSH, MTH, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
