Endocrinology Book

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Thyroxine Binding Globulin

Aka: Thyroxine Binding Globulin, Thyroid Binding Globulin, TBG
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  1. Physiology
    1. Radioimmunoassay of major storage of Thyroid hormone
    2. TBG binds Thyroid hormone in circulation
      1. Thyroxine (T4) is 99.97% protein bound
      2. Triiodothyronine (T3) is 99.7% protein bound
  2. Interpretation
    1. TBG effects measurement of total T4 and T3
      1. Increased TBG increases total T4 and T3 measurements
        1. Decreased percent Free T4 and T3
        2. No change in Free T4 and Free T3
      2. Decreased TBG decreases total T4 and T3 measurements
        1. Increased percent Free T4 and T3
        2. No change in Free T4 and Free T3
    2. Labs unaffected by Thyroid Binding Globulin (TBG)
      1. Free Thyroxine Index (FTI)
        1. Calculation based on T3 Resin Uptake
      2. Free Thyroxine (Free T4)
      3. Free Triiodothyronine (Free T3)
  3. Increased TBG (Reduces total T4 and T3 measurements)
    1. Pregnancy
    2. Newborn state
    3. Chronic Active Hepatitis
    4. Biliary Cirrhosis
    5. Infection
    6. Acute intermittent porphyria
    7. Familial hyperthyroxinemia
    8. Drugs
      1. Oral Contraceptives
      2. Estrogens
      3. Tamoxifen
      4. Methadone
      5. Heroin
      6. Perphenazine
  4. Decreased TBG (Elevates total T4 and T3 measurements)
    1. Chronic Liver Disease
    2. Obstructive Jaundice or Cirrhosis
    3. Severe systemic illness
    4. Active Acromegaly
    5. Nephrotic Syndrome
    6. Surgical Stress
    7. Medications
      1. Androgens
      2. Salicylates
      3. L-asparaginase
      4. Large doses of glucocorticoids (Prednisone)

Thyroxine-Binding Globulin (C0087090)

Definition (MSH) A thyroid hormone transport protein found in serum. It binds about 75% of circulating THYROXINE and 70% of circulating TRIIODOTHYRONINE.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D056825
SnomedCT 123338002, 143682007, 166320009, 166334009, 415720002, 88181004
English Thyroxine-Binding Globulin, TBG - Thyroxine binding globulin, TBG-Thyroxine binding globulin, Thyroxin binding globulin (TBG), Serpin A7, Thyroxine Binding Globulin, Thyropexin, Thyroxine-Binding Globulin [Chemical/Ingredient], tbg, thyroxine binding globulin (TBG), thyroxine binding globulin, Thyroxine binding glob., Thyroxine binding globulin -RETIRED-, Thyroxine binding globulin-TBG, TBG, Thyroxine binding globulin, Thyroxin-binding globulin, Thyroxine binding globulin (substance)
Spanish globulina fijadora de T4, Thyroxine binding glob., TBG - Thyroxine binding globulin, Thyroxine binding globulin, Thyroxine binding globulin-TBG, Globulina de Unión a Tiroxina, Globulina de Union a Tiroxina, globulina fijadora de tiroxina - RETIRADO - (concepto no activo), globulina fijadora de tiroxina - RETIRADO -, globulina fijadora de tiroxina, globulina fijadora de tiroxina (sustancia)
French Globuline liant la thyroxine, Globuline fixant la thyroxine, Globuline se liant à la thyroxine, TBG (Thyroxine-Binding Globulin), Globuline de liaison à la thyroxine
German Thyroxinbindendes Globulin
Portuguese Globulina Ligada a Tiroxina, Globulina Ligante de Tireoxina, Globulina Ligante de Tiroxina, Globulina Ligada a Tireoxina
Russian ТИРОКСИН-СВЯЗЫВАЮЩИЙ ГЛОБУЛИН, TIROKSIN-SVIAZYVAIUSHCHII GLOBULIN, ТИРОПЕКСИН, SERPIN A7, TIROPEKSIN, СЕРПИН A7
Swedish Tyroxinbindande globulin
Czech thyropexin, serpin A7, globulin vázající thyroxin
Italian Globulina legante la tiroxina
Polish Globulina wiążąca tyroksynę
Japanese チロキシン結合グロブリン, サイロキシン結合グロブリン
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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