Endocrinology Book

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Thyroid Stimulating HormoneAka: TSH, Serum TSH

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  1. Physiology
    1. See Thyroid Physiology
    2. Variation
      1. TSH levels follow a circadian rhythm
      2. Euthyroid individuals still have considerable variation in TSH levels over time
      3. Populations of euthyroid individuals also have considerable variation in TSH levels
    3. Regulation
      1. Negative feedback
        1. Unbound Thyroxine (Free T4)
        2. Unbound Triiodothyronine (Free T3)
      2. Positive Stimulation
        1. Thyroid Releasing Hormone (TRH)
  2. Interpretation
    1. Normal
      1. Random: 0.3 - 5.0 uIU/ml
      2. Following Thyroid Releasing Hormone (TRH) stimulation
        1. TSH: 9-30 uIU/ml at 20-30 min
    2. Borderline Increased: 5-10 uIU/ml
    3. High: >10 uIU/ml
  3. Increased TSH
    1. Hypothyroidism
    2. Drugs
      1. Haloperidol
      2. Chlorpromazine
      3. Metoclopramide
      4. Domperidone
    3. TSH antibodies
    4. Pituitary resistance
  4. Decreased TSH
    1. Hyperthyroidism
    2. Acute illness
    3. Hyponatremia
    4. Malnutrition
    5. Medications
      1. Dopamine
      2. Corticosteroids
      3. Bromocriptine
      4. Levodopa
      5. Pyridoxine

Thyrotropin (C0040160)

Definition (MSH)A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
Definition (CSP)glycoprotein hormone of the anterior pituitary that promotes the growth of, sustains, and stimulates hormonal secretion of the thyroid gland.
Definition (NCI)A hormone produced by the pituitary gland. TSH stimulates the release of thyroid hormone from thyroglobulin. It also stimulates the growth of thyroid follicular cells. An abnormal TSH level may mean that the thyroid hormonal regulation system is out of control, usually as a result of a benign condition (hyperthyroidism or hypothyroidism).
Definition (NCI)A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishThyreotropin, Thyroid stimulating hormone, Thyrotrophic hormone product, Thyrotrophin, Thyrotrophin product, Thyrotropic hormone preparation, Thyrotropin, TSH, TSH preparation
Spanishhormona estimulante tiroidea, hormona tiroideoestimulante, preparado de hormona tirotrófica, preparado de hormona tirotrópica, preparado de hormona tirotrofica, preparado de hormona tirotropica, preparado de tirotrofina, preparado de TSH, tirotrofina, tirotropina
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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