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TriiodothyronineAka: T3, Free T3

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  1. See Also
    1. Triiodothyronine Replacement
    2. Hypothyroidism
    3. Hyperthyroidism
  2. Normal Levels
    1. Triiodothyronine (T3): 80-180 ng/dl
    2. Free T3: 230-619 pg/dl
  3. Measurement
    1. T3 radioimmunoassay measures bound and free T3
      1. Affected by TBG levels as well as other factors
    2. Free Triiodothyronine (free T3) measures only active T3
      1. Not affected by Thyroid Binding Globulin (TBG)
      2. Represents 0.3% of total T3
    3. False Hypothyroidism if impaired T4 to T3 conversion
      1. Systemic illness
      2. Fasting
      3. Surgical stress
      4. Drugs
        1. Prednisone
        2. Propylthiouracil
        3. Amiodarone
        4. Radiopaque contrast
        5. Propranolol

Triiodothyronine (C0041014)

Definition (MSH)A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Definition (CSP)one of the thyroid hormones; an organic iodine containing compound secreted in small amounts by the thyroid gland; most circulating triiodothyroinine is produced by the deiodination of thyroxine in the peripheral tissues.
Definition (NCI)A thyroid hormone. Also called liothyronine sodium or T-3.
Definition (NCI)A thyroid hormone. Also called triiodothyronine or liothyronine sodium.
Definition (PDQ)A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C907" NCI Thesaurus)
Definition (NCI)A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
Definition (NCI)A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
EnglishL-Triiodothyronine, L-triiodothyronine preparation, Liothyronine, LIOTHYRONINE PREPARATION, T AAA THYROID HORMONE 003, T-3, T<sub>3</sub>, T<sub>3</sub> preparation, T>3<, T>3< preparation, T3, T3 - Liothyronine, T3 - Triiodothyronine, T3 preparation, T3 Thyroid Hormone, Therapeutic T3, therapeutic triiodothyronine, Total triiodothyronine, Tri-iodothyronine product, Triiodothyronine, Triiodothyronine preparation
Spanishliotironina, liotironina sodica, preparado con T<sub>3</sub>, preparado con T>3<, preparado con T3, preparado con triyodotironina, preparado de T<sub>3</sub>, preparado de T>3<, preparado de T3, preparado de triyodotironina, T3, triyodotironina
Parent ConceptsThyronine (C0282364), Thyroid Hormones (C0040135), Thyronines (C0040153), Thyroid preparation (C0279175), Triiodothyronine (C0041014), [HS851] THYROID SUPPLEMENTS (C0973568), Duplicate concept (C1274013)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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