Endocrinology Book

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Thyroid Releasing HormoneAka: TRH

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  1. Measurement
    1. Measures responsiveness of pituitary to TRH
  2. Protocol
    1. Administer TRH 500 ug
    2. Measure Thyroid Stimulating Hormone (TSH) at 30-60 min
  3. Interpretation of TSH
    1. Normal Response
      1. TSH rises 2-4x baseline
    2. Hyperthyroidism
      1. Low TSH with suppressed response to TRH
    3. Hypothyroidism
      1. High TSH with exaggerated TRH response

Thyrotropin-Releasing Hormone (C0040162)

Definition (CSP)tripeptide hormone elaborated by the median eminence of the hypothalamus which stimulates release of thyrotropin from the anterior pituitary gland.
Definition (NCI)Expressed (highest) in the medial hypothalamic paraventricular nuclei and median eminence by human TRH Gene, 242-aa 27-kDa (precursor) (prepro-)Thyrotropin-Releasing Hormone is a major regulator of TSH biosynthesis and release in the anterior pituitary gland and neurotransmitter/neuromodulator in the central and peripheral nervous systems. (NCI)
Definition (MSH)A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Neuroreactive Substance or Biogenic Amine (T124) , Hormone (T125)
EnglishPRL RH, Prolactin Releasing Hormone, Prolactin-Releasing Hormone, Protirelin, PROTIRELIN PREPARATION, Protirelin preparation -RETIRED-, Thyroid Releasing Hormone, Thyroid-Releasing Hormone, Thyroliberin, Thyrotrophin releasing hormone, Thyrotrophin-releasing hormone, Thyrotropin releasing factor, Thyrotropin releasing factor agent, Thyrotropin releasing hormone, Thyrotropin releasing hormone preparation, thyrotropin RH, Thyrotropin-Releasing Factor, Thyrotropin-Releasing Hormone, TRF, TRF - Protirelin, TRH, TRH - Protirelin, TRH - Thyrotrophin releasing hormone
Spanishagente con factor liberador de tirotrofina, factor liberador de tirotrofina, factor liberador de TSH, hormona liberadora de tirotrofina, hormona liberadora de TSH, preparado de hormona liberadora de tirotrofina, preparado de protirrelina, preparado de protirrelina-RETIRADO-, preparado de tiroliberina, preparado de TRH, protirelina
Parent ConceptsPolypeptide Hormones (C0312439), Hypothalamic Hormones (C0020656), Neuropeptides (C0027895), Oligopeptides (C0028954), Pituitary Hormone-Releasing Hormones (C0032014), Hormones (C0019932), [DX900] DIAGNOSTICS, OTHER (C0973537), Hypothalamic Releasing Factor (C0020660), Thyrotropin-Releasing Hormone (C0040162), Reason not stated concept (C1276325), Drug allergen (C1320237)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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