II. Pathophysiology

  1. Drugs are second most common cause of Neutropenia
  2. Induce hypoproliferation via marrow injury

III. Causes: Most common

  1. Chemotherapeutics (standard effect, see below)
  2. Thyroid inhibitors (Antithyroid Drugs)
  3. Trimethoprim-Sulfamethoxazole (Septra, Bactrim)
  4. Sulfasalazine
  5. Clomipramine
  6. Dipyrone
  7. Concurrent Analgesic use is predisposing factor

IV. Causes: Chemotherapeutics (most common causes)

  1. See Alkylating Agents
  2. See Antimetabolite Chemotherapy
  3. Anthracyclines (e.g. Doxorubicin, Daunorubicin)
  4. Taxanes (e.g. Paclitaxel, Docetaxel)
  5. Topoisomerase inhibitors (Etoposide)
  6. Platinum Chemotherapy (e.g. Cisplatin)
  7. Gemcitabine (Gemzar)
  8. Vinorelbine (Navelbine)
  9. [PubMed]

VIII. Causes: Analgesics

IX. Causes: Miscellaneous

X. References

  1. Lee (1999) Wintrobe's Hematology, Lippincott, p. 1862-9
  2. van der Klauw (1999) Arch Intern Med 159(4):369-74 [PubMed]

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