II. Indications
III. Contraindications
- Prolonged use longer than 6 months
- Prolonged use >14 days in age over 65 years (relative contraindication if normal Renal Function)
- Creatinine Clearance <30-40 ml/min (short-term use <14 days appears safe at GFR >30 ml/min)
- References
- (2018) Presc Lett 25(8)
- Oplinger (2013) Ann Pharmacother 47(1):106-11 [PubMed]
IV. Adverse Effects
- Pulmonary fibrosis
- Chronic Nitrofurantoin use
- Acute Nitrofurantoin Pulmonary Toxicity
V. Preparations
- Macrobid
- Capsules: 100 mg
- Nitrofurantoin
- Capsules: 25 mg, 50 mg, 100 mg
- Suspension: 25 mg per 5 ml
VI. Technique
- Take immediately after food to increase absorption
- Food decreases gastrointestinal upset
VII. Dosing: Adults
- Nitrofurantoin: 50 to 100 mg orally four times daily
- Macrobid: 100 mg orally twice daily
- Course: 5 days (instead of 7) is sufficient for uncomplicated UTI in non-pregnant women
VIII. Dosing: Children
- Nitrofurantoin: 5-7 mg/kg/day divided qid
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Related Studies
| nitrofurantoin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| NITROFURANTOIN MCR 100 MG CAP | Generic | $0.38 each |
| NITROFURANTOIN MCR 25 MG CAP | Generic | $3.49 each |
| NITROFURANTOIN MCR 50 MG CAP | Generic | $0.35 each |
| NITROFURANTOIN MONO-MCR 100 MG | Generic | $0.41 each |