II. Indication

III. Dose

  1. Dapsone 100 mg per day

IV. Adverse Effects

  1. Hemoglobin decreased (1-2 grams)
  2. Reticulocytes increased (2-12%)
  3. Hemolysis in G6PD Deficiency
  4. Methemoglobinemia
  5. Peripheral Neuropathy (rare)
  6. Nausea or Vomiting
  7. Proteinuria or Albuminuria
  8. Nephrotic Syndrome
  9. Erythema Nodosum leprosum in Leprosy treatment (50%)

V. Contraindications

VI. Monitoring

  1. Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)
    1. Screen for before starting Dapsone
  2. Complete Blood Count
    1. Obtain baseline and monthly while on Dapsone

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Cost: Medications

dapsone (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DAPSONE 100 MG TABLET Generic $1.02 each
DAPSONE 25 MG TABLET Generic $0.57 each
DAPSONE 5% GEL Generic $2.39 per gram
DAPSONE 7.5% GEL PUMP Generic $2.28 per gram