II. Mechanism
- Non-Selective Beta Blocker
-
Beta 1 Adrenergic Receptor
Antagonist
- Decreases Heart Rate, Cardiac Output, and Sympathetic System output (decreased renin release)
-
Beta 2 Adrenergic Receptor
Antagonist
- Risk of bronchoconstriction
III. Indications: Primary
IV. Indications: Selective Beta Blockers Preferred instead of Propranolol
V. Adverse Effects
- See Beta Blocker
- Transient Hypertension
- Beta 2 Adrenergic ReceptorAntagonists transiently constrict large arteries
- CNS Adverse Effects
- CNS penetration
- Rebound Hypertension
- Sudden discontinuation of Propranolol
VI. Drug Interactions
-
Cimetidine
- Increases Propanolol serum levels
VII. Dosing: Oral
- Regular: 40 mg PO bid (MAX: 640 mg/day)
- Extended: 80 mg PO qd (MAX: 320 mg/day)
VIII. Dosing: Intravenous
- Load: 1-3 mg IV over 2-5 minutes
- Repeat every 2 minutes to a total dose of 0.1 mg/kg
- Sustained response for 6-8 hours
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Related Studies
| propranolol (on 10/19/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| PROPRANOLOL 10 MG TABLET | Generic | $0.08 each |
| PROPRANOLOL 20 MG TABLET | Generic | $0.08 each |
| PROPRANOLOL 20 MG/5 ML SOLN | Generic | $0.09 per ml |
| PROPRANOLOL 40 MG TABLET | Generic | $0.10 each |
| PROPRANOLOL 60 MG TABLET | Generic | $0.29 each |
| PROPRANOLOL 80 MG TABLET | Generic | $0.22 each |
| PROPRANOLOL ER 120 MG CAPSULE | Generic | $0.27 each |
| PROPRANOLOL ER 160 MG CAPSULE | Generic | $0.38 each |
| PROPRANOLOL ER 60 MG CAPSULE | Generic | $0.20 each |
| PROPRANOLOL ER 80 MG CAPSULE | Generic | $0.20 each |