Mitotic Inhibitor Chemotherapy

Aka: Mitotic Inhibitor Chemotherapy, Mitosis Inhibitor Anticancer Agent, Mitosis Inhibitor, Antimicrotubular Agent, Antimitotic Agent, Plant Alkaloid Chemotherapy, Vinca Alkaloid, Taxane, Topoisomerase Inhibitor

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II. Medications: Mitotic Inhibitors

  1. Vinca Alkaloids
    1. Vinblastine (Velban)
    2. Vincristine (Oncovin)
    3. Vinorelbine
  2. Taxanes
    1. Paclitaxel (Taxol)
    2. Albumin-Bound Paclitaxel (Abraxane)
    3. DocetaxelTaxotere (Taxotere)
    4. Cabazitaxel (Jevtana)
  3. Topoisomerase 1 Inhibitors
    1. Topotecan (Hycamptin)
    2. Irinotecan (Camtosar)
    3. Irinotecan Liposome (Onivyde)
  4. Topoisomerase 2 Inhibitors
    1. Anthracyclines (e.g. Daunorubicin, Doxorubicin, Idarubicin, Mitoxantrone)
    2. Etoposide (VePesid, VP-16)
    3. Teniposide (Vumon, VM-26)
  5. Other
    1. Ixabepilone (Ixempra)
    2. Eribulin

III. Medications: Plant-Based Alkyloids

  1. Subset of the mitotic inhibitors listed above
  2. Vinca Alkaloids
    1. Inhibits mitosis (metaphase arrest)
    2. Cause disassembly of microtubules
    3. Periwinkle Plant (Vinca rosea) derivatives include Vinblastine and Vincristine
  3. Podophyllotoxins
    1. Block cells in S-G2 phase of cell cycle
    2. DNA degradation
    3. Nucleoside transport inhibition
    4. Mitochondrial electron transport inhibition
    5. Mayapple plant (Podophyllum peltatum) derivatives include Etoposide and Teniposide

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