II. Background

  1. Produced first in 1958 from penicillium

III. Indications

IV. Duration

  1. Tinea Capitis
    1. Treated for 6-8 weeks (durations up to 16 weeks have been used previously) or
    2. Two weeks after cultures are negative

V. Efficacy

  1. Very effective for Tinea Capitis over 2-4 months
  2. Not as effective for Tinea Unguium

VI. Dosing

  1. Ultrasize preparations are also available but are significantly more expensive (but better absorption)
  2. Griseofulvin microsize (Griseofulvin V)
    1. Adults: 500 mg (up to 1 g) orally daily
    2. Child: 10-20 mg/kg/day (up to 20-25 mg/kg/day, maximum 1 g/day) until Hair Growth

VII. Monitoring

  1. No baseline testing needed in the absence of liver disease
  2. Obtain labs for treatment duration >8 weeks (or history of abnormal Liver Function Tests)
    1. Liver Function Tests (ALT, AST, Serum Bilirubin) every 8 weeks
    2. Complete Blood Count (CBC) every 8 weeks
    3. Serum Creatinine every 8 weeks

VIII. Directions

  1. Take with food (especially a fatty meal) for better absorption

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Related Studies

Cost: Medications

griseofulvin (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
GRISEOFULVIN 125 MG/5 ML SUSP Generic $0.41 per ml
GRISEOFULVIN MICRO 500 MG TAB Generic $7.40 each
GRISEOFULVIN ULTRA 250 MG TAB Generic $4.45 each