Indications
1. Benzodiazepine Withdrawal
2. Barbiturate withdrawal
3. Sedative withdrawal
General
1. Equivalents to 60 mg Diazepam or 180 mg Phenobarbital
2. Equivalent = drug dose X Conversion factor
Benzodiazepines Equivalents to Diazepam 60 mg
1. Alprazolam (Xanax) 6 mg
  1. Valium = Dose x10
  2. Phenobarbital = Dose x30
2. Chlordiazepoxide (Limbitrol) 150 mg
  1. Valium = Dose x0.4
  2. Phenobarbital = Dose x1.2
3. Clonazepam (Klonopin) 24 mg
  1. Valium = Dose x2.5
  2. Phenobarbital = Dose x7.5
4. Flurazepam (Dalmane) 90 mg
  1. Valium = Dose x 0.6
  2. Phenobarbital = Dose x2.0
5. Halazepam (Paxipam) 240 mg
  1. Valium = Dose x0.25
  2. Phenobarbital = Dose x0.75
6. Lorazepam (Ativan) 12 mg
  1. Valium = Dose x5.0
  2. Phenobarbital = Dose x15.0
7. Oxazepam (Serax) 60 mg
  1. Valium = Dose x1.0
  2. Phenobarbital = Dose x3.0
8. Temazepam (Restoril) 60 mg
  1. Valium = Dose x1.0
  2. Phenobarbital = Dose x3.0
Barbiturate equivalents to Phenobarbital 180 mg
1. Butabarbital (Butisol) 600 mg
  1. Valium = Dose x0.1
  2. Phenobarbital = Dose x0.3
2. Pentobarbital (Nembutal) 600 mg
  1. Valium = Dose x0.1
  2. Phenobarbital = Dose x0.3
3. Secobarbital (Seconal) 600 mg
  1. Valium = Dose x0.1
  2. Phenobarbital = Dose x0.3
4. Phenobarbital 180 mg
  1. Valium = Dose x0.33
  2. Phenobarbital = Dose x1.0
Miscellaneous Sedative equivalents
1. Glycerol: Meprobamate (Equanil) 2400 mg
  1. Valium= Dose x0.025
  2. Phenobarbital = Dose x0.075
2. Piperidinedione: Glutethimide (Doriden) 1500 mg
  1. Valium = Dose x0.04
  2. Phenobarbital = Dose x0.12
3. Quinazoline: Methaqualone 1800 mg
  1. Valium = Dose x0.03
  2. Phenobarbital = Dose x0.1

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 11/3/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.