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FlurazepamAka: Dalmane

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  1. See Also
    1. Benzodiazepine
  2. Indications
    1. Insomnia
  3. Pharmacokinetics
    1. Half-Life: 24 to 100 hours
  4. Flurazepam (Dalmane)
    1. Dose: 15-30 mg PO qhs
  5. Dosing
    1. Max Daily Dose: 30 mg
  6. Cost
    1. 7 day cost: $1.50
  7. Precautions
    1. Drug accumulation in elderly
  8. Side Effects
    1. Daytime somnolence
  9. Advantages
    1. Long half life prevents rebound Insomnia
      1. often seen in other Benzodiazepines used >30 days
  10. Equivalents for Withdrawal protocol
    1. Valium = Flurazepam Dose x 0.6
    2. Phenobarbital = Flurazepam Dose x2.0

Flurazepam (C0016375)

Definition (MSH)A benzodiazepine derivative used mainly as a hypnotic.
Definition (CSP)benzodiazepine derivative used mainly as a sedative and hypnotic in the treatment of insomnia.
Definition (NCI)A member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD005479
EnglishFlurazepam, FLURAZEPAM PREPARATION
Spanishfluracepam, flurazepam
Parent ConceptsBenzodiazepinones (C0005065), Anticonvulsants (C0003286), Benzodiazepines (C0005064), Hypnotics and Sedatives (C0020592), Muscle relaxants (C0358430), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Benzodiazepine sedative (C0360114)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Dalmane (C0733803)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD005479
EnglishAllphar Brand of Flurazepam Monohydrochloride, Dalmadorm, Dalmane, Dormodor, ICN Brand of Flurazepam Monohydrochloride
SourcesAOD, MSH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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