II. Class

  1. Long Acting Benzodiazepine

III. Pharmacokinetics

  1. Half Life: 7-48 hours

IV. Dosing

  1. Anxiety Disorder
    1. Oral: 5 to 25 mg PO tid to qid
    2. Parenteral: 25 to 50 mg IM or IV tid to qid
  2. Alcohol Withdrawal
    1. Dose: 50 to 100 mg PO, IM or IV
    2. Repeat dosing every 3-4 hours up to 300 mg per day

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Cost: Medications

chlordiazepoxide (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CHLORDIAZEPOXIDE 10 MG CAPSULE Generic $0.07 each
CHLORDIAZEPOXIDE 25 MG CAPSULE Generic $0.07 each
CHLORDIAZEPOXIDE 5 MG CAPSULE Generic $0.09 each
CHLORDIAZEPOXIDE-CLIDINIUM CAP Generic $1.89 each

Ontology: Chlordiazepoxide (C0008188)

Definition (NCI) A long-acting benzodiazepine with anxiolytic, sedative and hypnotic activity. Chlordiazepoxide exerts its effect by binding to the benzodiazepine site at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA on the CNS.
Definition (MSH) An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Definition (CSP) anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties; also used in the symptomatic treatment of alcohol withdrawal.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002707
SnomedCT 372866006, 82746003
LNC LP16068-6, MTHU006722
English Methaminodiazepoxide, 7 Chloro N methyl 5 phenyl 3H 1,4 benzodiazepin 2 amine 4 oxide, 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide, 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide, 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide, chlordiazepoxide, chlordiazepoxide (discontinued), chlordiazepoxide (discontinued) (medication), Chlordiazepoxide, CHLORDIAZEPOXIDE, Chlordiazepoxide [Chemical/Ingredient], methaminodiazepoxide, chlordiazePOXIDE, Chlordiazepoxide (product), Chlordiazepoxide (substance)
Swedish Klordiazepoxid
Czech chlordiazepoxid
Finnish Klooridiatsepoksidi
Russian KHLOZEPID, LIBRIUM, NAPOTON, KHLORDIAZEPOKSID, METAMINODIAZEPOKSID, ELENIUM, ЛИБРИУМ, МЕТАМИНОДИАЗЕПОКСИД, НАПОТОН, ХЛОЗЕПИД, ХЛОРДИАЗЕПОКСИД, ЭЛЕНИУМ
Japanese クロルジアゼポキシド, メタミノジアゼポキシド
Italian Metaminodiazepossido, Clordiazepossido
Croatian KLORDIAZEPOKSID
Spanish clordiacepóxido (producto), clordiacepóxido, clordiazepóxido, clordiazepóxido (sustancia), clordiazepóxido (producto), Metaminodiazepóxido, Clorodiacepóxido, Clordiacepóxido, Librium, Clorodiazepóxido, Metaminodiacepóxido, clordiacepóxido (sustancia), Clordiazepóxido
Polish Chlordiazepoksyd, Elenium, Librium
Portuguese Librium, Clordiazepóxido, Metaminodiazepóxido
French Chlordiazépoxyde
German Chlordiazepoxid, Methaminodiazepoxid

Ontology: Librium (C0013881)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002707
English librium, Librium