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Temazepam

Aka: Temazepam, Restoril
  1. See Also
    1. Benzodiazepine
  2. Class
    1. Medium Acting Benzodiazepine
  3. Indications
    1. Insomnia with frequent awakening
  4. Dose
    1. Restoril 7.5 to 30 mg PO 1-2 hours before bedtime
  5. Pharmacokinetics
    1. Onset: 30-60 minutes
    2. Duration: 6-8 hours
    3. Half-Life: 8-12 hours
    4. Serum levels peak in 2-3 hours after oral dose
  6. Background
    1. Weekly Cost: $1-2
    2. Exception: 7.5 mg costs $200/month
  7. Advantages
    1. Less daytime Sedation or accumulation
  8. Disadvantages
    1. More risk of rebound Insomnia
  9. Equivalent dosing (for Benzodiazepine Withdrawal)
    1. Valium = Dose x1.0
    2. Phenobarbital = Dose x3.0

Restoril (C0723045)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D013693
German Restoril
English restoril, Restoril, Mallinckrodt Brand of Temazepam, Novartis Brand of Temazepam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Temazepam (C0039468)

Definition (MSH) A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Definition (NCI) A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D013693
SnomedCT 321143008, 334023006, 387300007, 54705000
English 3-Hydroxydiazepam, Hydroxydiazepam, Methyloxazepam, Oxydiazepam, Temazepam, 3 Hydroxydiazepam, 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-, Temazepam [anaesthesia], Temazepam [anesthesia], Temazepam [hypnotic], 10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one, temazepam, Temazepam [anesthesia] (product), Temazepam [hypnotic] (product), temazepam (medication), TEMAZEPAM, Temazepam [Chemical/Ingredient], Temazepam (product), Temazepam (substance), Temazepam [anesthesia] (substance), Temazepam [hypnotic] (substance)
Swedish Temazepam
Czech temazepam
Finnish Tematsepaami
Russian GIDROKSIDIAZEPAM, METILOKSAZEPAM, TEMAZEPAM, KAMAZEPAM, ГИДРОКСИДИАЗЕПАМ, КАМАЗЕПАМ, МЕТИЛОКСАЗЕПАМ, ТЕМАЗЕПАМ
Spanish temazepam [hipnótico], temazepam [anestésico] (producto), temazepam [anestésico], temazepam [hipnótico] (producto), temacepam (producto), temacepam (sustancia), temacepam, temazepam (sustancia), temazepam, Hidroxidiazepam, Metiloxazepam, Temazepam
Japanese テマゼパム, ヒドロキシジアゼパム, メチルオキサゼパム
Polish Temazepam
French Témazépam
German Hydroxydiazepam, Methyloxazepam, Temazepam, 3-Hydroxydiazepam, Oxydiazepam
Italian Temazepam
Portuguese Hidroxidiazepam, Metiloxazepam, Temazepam
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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