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TemazepamAka: Restoril

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  1. See Also
    1. Benzodiazepine
  2. Class
    1. Medium Acting Benzodiazepine
  3. Indications
    1. Insomnia with frequent awakening
  4. Dose
    1. Restoril 7.5 to 30 mg PO 1-2 hours before bedtime
  5. Pharmacokinetics
    1. Onset: 30-60 minutes
    2. Duration: 6-8 hours
    3. Half-Life: 8-12 hours
    4. Serum levels peak in 2-3 hours after oral dose
  6. Background
    1. Weekly Cost: $1-2
    2. Exception: 7.5 mg costs $200/month
  7. Advantages
    1. Less daytime Sedation or accumulation
  8. Disadvantages
    1. More risk of rebound Insomnia
  9. Equivalent dosing (for Benzodiazepine Withdrawal)
    1. Valium = Dose x1.0
    2. Phenobarbital = Dose x3.0

Temazepam (C0039468)

Definition (MSH)A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
Definition (NCI)A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD013693
English3 Hydroxydiazepam, 3-Hydroxydiazepam, Hydroxydiazepam, Methyloxazepam, Oxydiazepam, Temazepam, TEMAZEPAM PREPARATION
Spanishtemacepam, temazepam
Parent ConceptsBenzodiazepinones (C0005065), Benzodiazepines (C0005064), [CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS (C0973503), Temazepam (C0039468), Benzodiazepine sedative (C0360114)
SourcesAOD, LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Restoril (C0723045)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD013693
EnglishMallinckrodt Brand of Temazepam, Novartis Brand of Temazepam, Restoril
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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