The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
Definition (NCI)
A synthetic substance related to natural sympathomimetic amines and the synthetic agent amphetamine. In the central nervous system (CNS), dextroamphetamine induces the release of dopamine within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria. As a CNS stimulant, this agent may increase blood pressure and reduce appetite. Similar to other amphetamines, dextroamphetamine has a high potential for abuse, dependence, and addiction if used in large doses over extended periods of time. (NCI04)
Definition (CSP)
d-form of amphetamine; it is a central nervous system stimulant and a sympathomimetic; it has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children; dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase; it is also a drug of abuse and a psychotomimetic.
Concepts
Organic Chemical (T109)
, Pharmacologic Substance (T121)
MSH
D003913
SnomedCT
50868004, 387278002, 409880008
English
Dexamphetamine, d Amphetamine, d-Amphetamine, dextro Amphetamine, dextro-Amphetamine, dextroamphetamine, Benzeneethanamine, alpha-methyl-, (S)-, Dexamfetamine, AMPHETAMINE A D, D amphetamine, Dextroamphetamine, (+)-Amphetamine, Dextroamphetamine [Chemical/Ingredient], dexamphetamines, d amphetamine, dextro-amphetamine, dextro amphetamine, d-amphetamine, dextroamphetamines, d amphetamines, amphetamines d, Dextroamphetamine (product), Dextroamphetamine (substance), Amphetamine (d-), DEXTROAMPHETAMINE, dexamphetamine, Dexamfetamine (substance)
A prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria, mental alertness and excitement and appetite suppression. As a CNS stimulant, this agent may increase blood pressure.
Concepts
Organic Chemical (T109)
, Pharmacologic Substance (T121)