Infectious Disease Book

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DTaP Vaccine

Aka: DTaP Vaccine, DTaP, Diphtheria Tetanus Acellular Pertussis Vaccine
  1. Epidemiology
    1. DiphtheriaIncidence
      1. U.S. (1993) No Cases of Diphtheria
      2. Entire Soviet Union (1982) 340 cases
      3. Russia alone (1994) 40,000 cases
    2. Pertussis
      1. Incidence in U.S. reached a low of 1020 cases 1976
      2. Increasing in Incidence in U.S. over last 20 years
      3. Incidence in U.S. 24,000 cases in 2003
        1. Two thirds of cases occur in teens and adults
      4. Adult cases often mild, but infant cases are severe
  2. Indications
    1. Acellular Pertussis vaccine approved for all ages
    2. Should be used in Primary Series
  3. Contraindications: DTP or DTaP administration
    1. Absolute: Severe reaction following prior DTP or DTaP
      1. Immediate Anaphylaxis
      2. Encephalopathy within 7 days of Vaccine
    2. Relative: Moderate Reaction following prior DTP or DTaP
      1. Fever > 40.5 C within 48 hours of vaccine
      2. Seizure within 72 hours of vaccine
      3. Hypotension or Unresponsive Episode within 48 hours
      4. Inconsolable Crying >3 hours within 48 hours
      5. Guillain-Barre Syndrome within 6 weeks of vaccine
    3. Conditions not contraindicating vaccine
      1. Family History of adverse vaccine event
      2. Family History of SIDS
      3. Family of Seizure disorder
      4. Fever following prior vaccine <40.5 C (105 F)
    4. If Vaccine Contraindicated, then
      1. Allergy Testing for anaphylactic reaction
      2. Administer DT to all other groups
  4. Efficacy (after 3 doses)
    1. Cellular vaccine: only 50% effective
    2. Acellular vaccine: 85% effective
  5. Preparations (Use one consistently for Primary Series)
    1. Tripedia
    2. ACEL-IMUNE
    3. Infanrix
  6. Schedule: Primary Series with DTaP Vaccine
    1. Dose 1: 2 months
    2. Dose 2: 4 months
    3. Dose 3: 6 months
    4. Dose 4: 15 to 18 months (may be given at 12 months)
    5. Dose 5: 4 to 6 years
  7. Adverse Effects: Acellular vaccine
    1. Marked reduction in adverse effects
    2. Compare with whole cell vaccine
      1. Lower fever
      2. Very low to no Incidence of Seizures or shock state
  8. Adverse Effects: Whole cell vaccine
    1. Mild Reaction to vaccine (75%)
      1. Local ache
      2. Induration
      3. Fever (<39.5)
    2. Moderate
      1. Fever >40.0-40.5
      2. Excess somnolence
      3. Inconsolable crying >4 hours
    3. Severe
      1. Neurologic changes within 3 days of vaccine
      2. Convulsions
      3. Acute encephalopathy
  9. Dosage Protocols
    1. Not compatible with HaemophilusInfluenza B Vaccine
      1. Reduced immunogenicity when mixed acellular Pertussis
    2. References
      1. 1996 N Engl J Med 334:341-55,391-2
      2. 1996 JAMA 275:37

Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed (C0694728)

Definition (NCI) A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and acellular pertussis antigens, adsorbed on aluminum phosphate, with active immunizing activity against diphtheria, tetanus and pertussis. The acellular pertussis vaccine components, produced by Bordetella pertussis, are detoxified pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN) and fimbriae types 2 and 3 (FIM). Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin, diphtheria toxin and B. pertussis antigens.
Definition (HL7V3.0) diphtheria, tetanus toxoids and acellular pertussis vaccine
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
HL7 20, 107
English diphtheria, tetanus, and pertussis (DTaP) vaccine, dtap, Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed, DTaP, DTaP, NOS
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Diphtheria-Tetanus-acellular Pertussis Vaccines (C0535644)

Definition (MSH) Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D022681
Swedish Difteri-stelkramp-acellulära kikhostevacciner
Czech diftérie-tetanus-acelulární pertuse - vakcíny, DTaP vakcíny
Finnish Soluttomat PDT-rokotteet
Russian DIFTERIINO-STOLBNIACHNO-ATSELLIULIARNOKOKLIUSHNYE VAKTSINY, VAKTSINY DIFTERIINO-STOLBNIACHNO-ATSELLIULIARNOKOKLIUSHNYE, ВАКЦИНЫ ДИФТЕРИЙНО-СТОЛБНЯЧНО-АЦЕЛЛЮЛЯРНОКОКЛЮШНЫЕ, ДИФТЕРИЙНО-СТОЛБНЯЧНО-АЦЕЛЛЮЛЯРНОКОКЛЮШНЫЕ ВАКЦИНЫ
English diphtheria, tetanus, and acellular pertussis (DTaP) vaccine, diphtheria, tetanus, and acellular pertussis (DTaP) vaccine (medication), Diphtheria-Tetanus-acellular Pertussis Vaccines [Chemical/Ingredient], dtap vaccine, Pertussis Vaccines, Diphtheria-Tetanus-acellular, Vaccine, DTaP, Vaccines, DTaP, Vaccines, Diphtheria-Tetanus-acellular Pertussis, DTaP Vaccine, DTaP Vaccines, Diphtheria Tetanus acellular Pertussis Vaccines, Diphtheria-Tetanus-acellular Pertussis Vaccines
Japanese ワクチン-ジフテリア・破傷風・無細胞百日咳, ジフテリア・破傷風・無細胞百日咳ワクチン, DTaPワクチン, ジフテリア-破傷風-無細胞百日咳ワクチン, ワクチン-DTaP, ワクチン-ジフテリア-破傷風-無細胞百日咳
Italian Vaccini DTaP, Vaccino DTaP, Vaccini tetanici, difterici e pertossici acellulari
Polish Szczepionki bezkomórkowe przeciw błonicy tężcowi krztuścowi
German DTaP-Impfstoffe, DTaP-Vakzinen, Diphtherie-Tetanus-azelluläre-Pertussis-Vakzine, Impfstoffe, Diphtherie-Tetanus-azelluläre Pertussis
Portuguese Vacinas DTaP, Vacinas Antidiftéricas, Antitetânicas e Anticoqueluche Acelular, Vacinas Antidiftéricas, Antitetânicas e Antipertússis Acelular, Vacinas contra Difteria, Tétano e Coqueluche Acelular, Vacinas contra Difteria, Tétano e Pertússis Acelular
French Vaccins DTCa, Vaccins diphtérique tétanique coquelucheux acellulaires
Spanish Vacunas DTaP, Vacunas Antidiftericas, Antitetanicas y Antipertussis Acelular, Vacunas Antidiftericas, Antitetanicas y Antitos Ferina Acelular, Vacunas Antidiftéricas, Antitetánicas y Antipertussis Acelular, Vacunas Antidiftéricas, Antitetánicas y Antitos Ferina Acelular, Vacunas contra Difteria, Tetanos y Pertussis Acelular, Vacunas contra Difteria, Tetanos y Tos Ferina Acelular, Vacunas contra Difteria, Tétanos y Pertussis Acelular, Vacunas contra Difteria, Tétanos y Tos Ferina Acelular
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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