Medication Causes of Impotence

Aka: Medication Causes of Impotence, Impotence due to Medication, Erectile Dysfunction due to Medication

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II. Causes: Cardiovascular agents

  1. Antihypertensive Medications
    1. Beta Blockers
    2. Calcium Channel Blockers
    3. Alpha Adrenergic Antagonists
      1. Methyldopa (Aldomet)
      2. Reserpine
      3. Terazosin (Hytrin)
      4. Doxazosin (Cardura)
    4. Centrally acting Alpha Adrenergic Agonists
      1. Clonidine (Catapres)
    5. Diuretics
      1. Thiazide Diuretics
      2. Spironolactone (Aldactone)
  2. Miscellaneous cardiovascular agents
    1. Clofibrate
    2. Gemfibrozil (Lopid)
    3. Digoxin
    4. Disopyramide (Norpace)

III. Causes: Psychiatric Medications

  1. Sedatives, Tranquilizers and Anxiolytics
    1. Benzodiazepines
    2. Phenothiazines
    3. Butyrophenones
    4. Phenothiazines
  2. Antipsychotics
    1. Chlorpromazine
    2. Haloperidol
    3. Pimozide (Orap)
    4. Thioridazine
    5. Thiothixene
  3. Antidepressants
    1. See Antidepressant Induced Sexual Dysfunction
    2. Monoamine Oxidase Inhibitors (MAO Inhibitors)
    3. Selective Serotonin Reuptake Inhibitors (SSRI)
    4. Tricyclic Antidepressants
    5. Lithium

IV. Causes: Neurologic Medications

  1. Anticonvulsants
    1. Phenytoin
    2. Phenobarbital
  2. Anti-Parkinson agents
    1. Bromocriptine
    2. Levodopa
    3. Trihexyphenidyl

V. Causes: Endocrine

  1. 5-alpha reductase inhibitors (Finasteride or Proscar)
  2. Luteinizing Hormone Releasing HormoneAgonist (LHRH)
  3. Corticosteroids
  4. Estrogen or Progesterone

VI. Causes: Miscellaneous

  1. Anticholinergic Medications
    1. Antihistamines (e.g. Diphenhydramine, Hydroxyzine)
    2. Vertigo agents (e.g. Dimenhydrinate, meclizine)
    3. Promethazine (Phenergan)
    4. H2 Antagonists: Cimetidine (Tagamet)
    5. Metoclopramide (Reglan)
  2. Immunomdulators and immune suppressants
    1. Interferon-alfa
    2. Methotrexate
  3. Analgesics
    1. NSAIDs
    2. Opioids
  4. Illicit Drugs
    1. Amphetamine and Methamphetamine
    2. Barbiturates
    3. Cocaine
    4. Heroin
    5. Marijuana

VII. References

  1. Heidelbaugh (2010) Am Fam Physician 81(3): 305-12 [PubMed]
  2. McVary (2007) N Engl J Med 357(24): 2472-81 [PubMed]

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