II. Indications
-
Hypertension
- Not first-line Antihypertensives, and avoid using as monotherapy (higher risk of CVA and CHF)
-
Benign Prostatic Hypertrophy
- Selective Alpha-1a Antagonists (e.g. Tamsulosin) are preferred
-
Medical Expulsive Therapy for Ureteral Stone
- Replaced by the preferred Selective Alpha-1a Antagonists (e.g. Tamsulosin)
III. Dosing
-
Hypertension
- Start 1 mg orally at bedtime
- Titrate to effective dose 1 to 5 mg daily or in divided doses
- Maximum 20 mg/day
-
Benign Prostatic Hypertrophy (replaced by Selective Alpha-1a Antagonists)
- Start 1 mg orally at bedtime
- Titrate to effect by doubling dose every 1-2 weeks (to 2, 5 and 10 mg)
- Observe for effects after 4 to 6 weeks on optimal dose (typically 10 mg)
- Maximum of 20 mg/day
IV. Safety
- Pregnancy Category C
- Unknown safety in Lactation
V. Mechanism
- See Alpha Adrenergic Receptor (Alpha-1 Antagonist)
-
Peripheral Alpha-1 Adrenergic Antagonist
- Arterial and Venous Vasodilation
VI. Adverse Effects
VII. Resources
VIII. References
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 62-3
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
| terazosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TERAZOSIN 1 MG CAPSULE | Generic | $0.14 each |
| TERAZOSIN 10 MG CAPSULE | Generic | $0.16 each |
| TERAZOSIN 2 MG CAPSULE | Generic | $0.14 each |
| TERAZOSIN 5 MG CAPSULE | Generic | $0.16 each |