III. Dosing

  1. Start 0.4 mg orally daily
  2. Maximum 0.8 mg/day

IV. Adverse Effects

  1. See Selective Alpha-1a Antagonist
  2. Rare Sulfa Allergy cross-reactivity
  3. Postural Hypotension (esp. when combined with Antihypertensives)
  4. Floppy Iris Syndrome
  5. Ejaculatory Dysfunction (class effect)

V. Drug Interactions

  1. Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
  2. Avoid Tamsulosin with strong CYP2D6 Inhibitors (e.g. Fluoxetine)

VII. References

  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/

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Cost: Medications

tamsulosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TAMSULOSIN HCL 0.4 MG CAPSULE Generic $0.06 each