II. Indications

  1. Used at low dose to "boost" most of the Protease Inhibitors

III. Mechanism

IV. Efficacy

  1. Very effective with Zidovudine (AZT) as well as other Protease Inhibitors

V. Adverse Effects (less common with the lower, "boosting dose")

  1. Gastrointestinal adverse effects may limit medication use
    1. Nausea or Vomiting
    2. Diarrhea
  2. Asthenia
  3. Paresthesias (Circumoral or peripheral)
  4. Triglycerides elevated
  5. Liver Function Tests
    1. Cholestatic enzymes elevated
    2. Hepatic transaminases elevated

VI. Drug Interactions

  1. Rifampin
  2. Dexamethasone
  3. Anticonvulsants

VII. Dosing

  1. Take with food
  2. Anticipate bad taste (Mix with chocolate milk)
  3. Full dose: 600 mg bid (not typically used at full dose due to adverse effects)
  4. Boosting dose varies from 100 mg daily up to 400 mg bid

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Related Studies

Cost: Medications

ritonavir (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
RITONAVIR 100 MG TABLET Generic $1.08 each
norvir (on 4/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
NORVIR 100 MG TABLET Generic $1.08 each