II. Indications
- Used at low dose to "boost" most of the Protease Inhibitors
III. Mechanism
IV. Efficacy
- Very effective with Zidovudine (AZT) as well as other Protease Inhibitors
V. Adverse Effects (less common with the lower, "boosting dose")
- Gastrointestinal adverse effects may limit medication use
- Asthenia
- Paresthesias (Circumoral or peripheral)
- Triglycerides elevated
-
Liver Function Tests
- Cholestatic enzymes elevated
- Hepatic transaminases elevated
VI. Drug Interactions
- Rifampin
- Dexamethasone
- Anticonvulsants
VII. Dosing
- Take with food
- Anticipate bad taste (Mix with chocolate milk)
- Full dose: 600 mg bid (not typically used at full dose due to adverse effects)
- Boosting dose varies from 100 mg daily up to 400 mg bid
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