II. Precautions
- Hepatotoxicity risk (FDA black box warning)
- Oral forumulation indicated only for severe, refractory systemic fungal infections due to Ketoconazole hepatotoxicity
- No longer indicated in Skin Infections
- If Ketoconazole is used, requires Liver Function Tests at baseline and again weekly
III. Adverse Effects: Oral (systemic formulation)
- Nausea
- Headache
- Liver toxicity (Hepatotoxicity)
- Adrenal Insufficiency
- Hyperkalemia
IV. Drug Interactions: Oral (systemic formulation)
- Serious Cardiac Arrhythmia with Hismanal or Seldane (off market in U.S.)
- Multiple other Drug Interactions
- CYP2C9 Inhibitor
- CYP3A3 Inhibitor and CYP3A4 Inhibitor
V. Lab monitoring: Oral (systemic formulation)
- Follow Liver Function Tests at baseline and weekly
VI. Directions
- Taking with food decreases gastric irritation
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Related Studies
| ketoconazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| KETOCONAZOLE 2% CREAM | Generic | $0.31 per gram |
| KETOCONAZOLE 2% SHAMPOO | Generic | $0.10 per ml |
| KETOCONAZOLE 200 MG TABLET | Generic | $0.68 each |