Efavirenz

Aka: Efavirenz, Sustiva, EFV

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II. Class

  1. Anti-retroviral agent
  2. Non-Nucleoside Reverse Transcriptase Inhibitor
    1. First generation agent

III. Indications: HIV and AIDS

  1. Most commonly used NNRTI in 2011 and available in combination (Atripla)

IV. Dosing

  1. Adult
    1. Efavirenz 600 mg qhs
  2. Child
    1. Weight 10-14 kg: 200 mg qhs
    2. Weight 15-19 kg: 250 mg qhs
    3. Weight 20-24 kg: 300 mg qhs
    4. Weight 25-32 kg: 350 mg qhs
    5. Weight 32-40 kg: 400 mg qhs

V. Adverse Effects

  1. General: CNS effects
    1. Onset 1-3 hours after dose
    2. Symptoms abate over 1-2 weeks
  2. CNS adverse effects (affects 50% at 1 month, 23% at 3 months, baseline at 6 months)
    1. Dizziness
    2. Headache
    3. Insomnia
    4. Difficulty concentrating
    5. Vivid dreams
    6. Nightmares
    7. Hallucinations

VI. Pregnancy

  1. Potentially Teratogenic

VII. Drug Interactions

  1. Take on empty Stomache at bedtime
  2. Induces CYP3A4 enzyme
  3. Decreases serum levels of some Protease Inhibitors
    1. Avoid concurrent use of Saquinavir
    2. Raise dose of Indinavir to 1000 mg PO q8h
  4. Decreases some Macrolide levels
    1. Decreases Clarithromycin level
    2. Azithromycin not effected

VIII. Labs

  1. Causes False Positive drug screen for Cannabinoids, Benzodiazepines

IX. Reference

  1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]

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Related Studies

Cost: Medications

efavirenz (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
EFAVIRENZ-EMTRICITABINE-TENOFOV DISOP FUM 600-200-300 MG TAB Generic $4.50 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Related Topics in Pharmacology

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