II. Preparations

  1. Emtricitabine (Emtriva, Coviracil)
  2. Emtricitabine with Tenofovir (Truvada TDF or Descovy TAF)

IV. Adverse Effects: Emtricitabine alone

  1. See nRTI for adverse effects attributed to the class
  2. Minimal specific adverse effects and well tolerated
  3. Hyperpigmentation of palms and soles
  4. Hepatitis B infection flares on withdrawal of medication

V. Adverse Effects: Emtricitabine with Tenofovir (Truvada, Descovy)

  1. See Tenofovir
  2. Start-up syndrome (Nausea, Abdominal Pain, Flatulence, Headache) which typically resolves after the first month
  3. Hepatitis B Virus flare
    1. Associated with abrupt cessation of Antiretroviral therapy
  4. Acute Renal Failure
    1. Risk when Truvada is combined with multiple dose or high dose NSAIDs
    2. May be less risk with Descovy (uses Tenofovir TAF instead of TDF)

VI. Protocol: HIV Prevention

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Cost: Medications

emtricitabine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
truvada (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TRUVADA 200 MG-300 MG TABLET Generic $0.56 each
descovy (on 1/1/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DESCOVY 200-25 MG TABLET $66.13 each