II. Mechanism
III. Efficacy
- Very effective in combination with Zidovudine (AZT)
IV. Dosing
- Indinavir 600 mg PO tid ($360/month)
- Take on empty Stomach
- One hour before or 2 hours after a meal
- Concurrent food reduces concentration up to 80%
- Drink at least 1.5 Liters (50 oz) liquid per day
- Drink 150 ml water per hour for 3 hours after dose
- Avoids Nephrolithiasis and Interstitial Nephritis
V. Adverse Effects
- See Protease Inhibitor for adverse effects attributed to the class
- Well tolerated
- Indirect Bilirubin elevation in 10% of patients
- Nephrolithiasis in 2-3% of patients
- Renal Insufficiency
- Alopecia
- Dry Skin
- Xerostomia
- Paronychia
- Gallstones
VI. Drug Interactions
-
St. John's Wort
- May reduce Indinavir concentrations by 80%
- Piscitelli (2000) Lancet 355:547-8 [PubMed]