II. Mechanism

III. Disadvantages

  1. Weak effect
  2. Expensive
  3. May worsen resistance for better drugs

IV. Adverse Effects

  1. Rash
  2. Prolonged QT Interval
  3. Hyperprolactinemia (rare)

V. Drug Interactions

  1. Garlic supplements (do not use with Saquinavir)
    1. Reduces Saquinavir concentrations by 50%
    2. Levels may remain reduced even after stopiing Garlic
    3. Piscitelli (2002) Clin Infect Dis 34:234-8 [PubMed]

VI. Dosing

  1. Saquinavir 600 mg PO tid ($572/month)
  2. If taken without food, may have no antiviral activity
    1. Take within 2 hours after a full meal
    2. Meals increase absorption and decrease GI upset

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