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Osteoporosis Secondary to MedicationAka: Drug-Induced Osteoporosis, Medication Causes of Osteoporosis

See Also
Causes: Anticonvulsants
1. General
  1. Anticonvulsants accelerate bone loss in elderly by 70%
2. Agents that increase Vitamin D and sex steroid metabolism
  1. Dilantin
  2. Phenobarbital
  3. Carbamazepine
  4. Primidone
3. Agents that increase renal calcium excretion
  1. Valproic Acid
4. References
  1. Ensrud (2004) Neurology 62(11):2051
Causes: General
1. Corticosteroids (systemic and inhaled)
  1. See Corticosteroid Associated Osteoporosis
2. Heparin (prolonged use)
3. Levothyroxine at excess doses (not when TSH normal)
4. Aromatase Inhibitors (e.g. Femara or Letrozole)
5. GnRH agonists
6. Cyclosporine
7. Tacrolimus
8. Phenothiazines
9. Methotrexate (at higher doses for longer duration)
10. Vitamin D in excess (>2000 units per day)
11. Vitamin A in excess (>10,000 units per day)

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This page was written by Scott Moses, MD. This page was last revised on 5/2/2008 9:32:02 AM. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.